Motor Neuron Generation from iPSCs from Identical Twins Discordant for Amyotrophic Lateral Sclerosis

Motor Neuron Generation from iPSCs from Identical Twins Discordant for Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disorder characterized by the loss of the upper and lower motor neurons. Approximately 10% of cases are caused by specific mutations in known genes, with the remaining cases having no known genetic link. As such, sporadic cases have...

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Bibliographic Details
Main Authors: Emily R. Seminary, Stephanie Santarriaga, Lynn Wheeler, Marie Mejaki, Jenica Abrudan, Wendy Demos, Michael T. Zimmermann, Raul A. Urrutia, Dominic Fee, Paul E. Barkhaus, Allison D. Ebert
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cells
Subjects:
induced pluripotent stem cells
protein aggregation
glutamate toxicity
sod1
c9orf72
sporadic als
familial als
Online Access:https://www.mdpi.com/2073-4409/9/3/571

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