Multidose Streptozotocin Induction of Diabetes in BALB/c Mice Induces a Dominant Oxidative Macrophage and a Conversion of TH1 to TH2 Phenotypes During Disease Progression

Macrophages (Mp) are implicated in both early and late phases in type 1 diabetes development. Recent study has suggested that a balance between reductive Mp (RMp) and oxidative Mp (OMp) is possible to regulate TH1/TH2 balance. The aim of this study is to investigate the redox status of peritoneal Mp...

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Bibliographic Details
Main Authors: Naxin Sun, Guiwen Yang, Heng Zhao, Huub F. J. Savelkoul, Liguo An
Format: Article
Language:English
Published: Hindawi Limited 2005-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/MI.2005.202