X Inactivation and Progenitor Cancer Cells
In mammals, silencing of one of the two X chromosomes is necessary to achieve dosage compensation. The 17 kb non-coding RNA called Xist triggers X inactivation. Gene silencing by Xist can only be achieved in certain contexts such as in cells of the early embryo and in certain hematopoietic progenito...
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MDPI AG
2011-04-01
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| Series: | Cancers |
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| Online Access: | http://www.mdpi.com/2072-6694/3/2/2169/ |
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doaj-091d48f91d454aff98f063baccf52f632020-11-24T23:28:22ZengMDPI AGCancers2072-66942011-04-01322169217510.3390/cancers3022169X Inactivation and Progenitor Cancer CellsRuben AgreloIn mammals, silencing of one of the two X chromosomes is necessary to achieve dosage compensation. The 17 kb non-coding RNA called Xist triggers X inactivation. Gene silencing by Xist can only be achieved in certain contexts such as in cells of the early embryo and in certain hematopoietic progenitors where silencing factors are present. Moreover, these epigenetic contexts are maintained in cancer progenitors in which SATB1 has been identified as a factor related to Xist-mediated chromosome silencing.http://www.mdpi.com/2072-6694/3/2/2169/X inactivationXist RNAchromatincancerepigenetics |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Ruben Agrelo |
| spellingShingle |
Ruben Agrelo X Inactivation and Progenitor Cancer Cells Cancers X inactivation Xist RNA chromatin cancer epigenetics |
| author_facet |
Ruben Agrelo |
| author_sort |
Ruben Agrelo |
| title |
X Inactivation and Progenitor Cancer Cells |
| title_short |
X Inactivation and Progenitor Cancer Cells |
| title_full |
X Inactivation and Progenitor Cancer Cells |
| title_fullStr |
X Inactivation and Progenitor Cancer Cells |
| title_full_unstemmed |
X Inactivation and Progenitor Cancer Cells |
| title_sort |
x inactivation and progenitor cancer cells |
| publisher |
MDPI AG |
| series |
Cancers |
| issn |
2072-6694 |
| publishDate |
2011-04-01 |
| description |
In mammals, silencing of one of the two X chromosomes is necessary to achieve dosage compensation. The 17 kb non-coding RNA called Xist triggers X inactivation. Gene silencing by Xist can only be achieved in certain contexts such as in cells of the early embryo and in certain hematopoietic progenitors where silencing factors are present. Moreover, these epigenetic contexts are maintained in cancer progenitors in which SATB1 has been identified as a factor related to Xist-mediated chromosome silencing. |
| topic |
X inactivation Xist RNA chromatin cancer epigenetics |
| url |
http://www.mdpi.com/2072-6694/3/2/2169/ |
| work_keys_str_mv |
AT rubenagrelo xinactivationandprogenitorcancercells |
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