Advances in Cell Transplantation Therapy for Diseased Myocardium

The overall objective of cell transplantation is to repopulate postinfarction scar with contractile cells, thus improving systolic function, and to prevent or to regress the remodeling process. Direct implantation of isolated myoblasts, cardiomyocytes, and bone-marrow-derived cells has shown prospec...

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Main Authors:	Outi M. Villet, Antti Siltanen, Tommi Pätilä, M. Ali A. Mahar, Antti Vento, Esko Kankuri, Ari Harjula
Format:	Article
Language:	English
Published:	Hindawi Limited 2011-01-01
Series:	Stem Cells International
Online Access:	http://dx.doi.org/10.4061/2011/679171

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spelling	doaj-091154c0cc0644e695470a9af2f0057d2020-11-24T23:16:59ZengHindawi LimitedStem Cells International1687-966X1687-96782011-01-01201110.4061/2011/679171679171Advances in Cell Transplantation Therapy for Diseased MyocardiumOuti M. Villet0Antti Siltanen1Tommi Pätilä2M. Ali A. Mahar3Antti Vento4Esko Kankuri5Ari Harjula6Department of Cardiothoracic Surgery, University of Helsinki Meilahti Hospital, P.O. Box 340, FIN-00029 HUS, FinlandDepartment of Pharmacology, Institute of Biomedicine, University of Helsinki, 00014 Helsinki, FinlandDepartment of Cardiothoracic Surgery, University of Helsinki Meilahti Hospital, P.O. Box 340, FIN-00029 HUS, FinlandDepartment of Cardiothoracic Surgery, University of Helsinki Meilahti Hospital, P.O. Box 340, FIN-00029 HUS, FinlandDepartment of Cardiothoracic Surgery, University of Helsinki Meilahti Hospital, P.O. Box 340, FIN-00029 HUS, FinlandDepartment of Pharmacology, Institute of Biomedicine, University of Helsinki, 00014 Helsinki, FinlandDepartment of Cardiothoracic Surgery, University of Helsinki Meilahti Hospital, P.O. Box 340, FIN-00029 HUS, FinlandThe overall objective of cell transplantation is to repopulate postinfarction scar with contractile cells, thus improving systolic function, and to prevent or to regress the remodeling process. Direct implantation of isolated myoblasts, cardiomyocytes, and bone-marrow-derived cells has shown prospect for improved cardiac performance in several animal models and patients suffering from heart failure. However, direct implantation of cultured cells can lead to major cell loss by leakage and cell death, inappropriate integration and proliferation, and cardiac arrhythmia. To resolve these problems an approach using 3-dimensional tissue-engineered cell constructs has been investigated. Cell engineering technology has enabled scaffold-free sheet development including generation of communication between cell graft and host tissue, creation of organized microvascular network, and relatively long-term survival after in vivo transplantation.http://dx.doi.org/10.4061/2011/679171
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Outi M. Villet Antti Siltanen Tommi Pätilä M. Ali A. Mahar Antti Vento Esko Kankuri Ari Harjula
spellingShingle	Outi M. Villet Antti Siltanen Tommi Pätilä M. Ali A. Mahar Antti Vento Esko Kankuri Ari Harjula Advances in Cell Transplantation Therapy for Diseased Myocardium Stem Cells International
author_facet	Outi M. Villet Antti Siltanen Tommi Pätilä M. Ali A. Mahar Antti Vento Esko Kankuri Ari Harjula
author_sort	Outi M. Villet
title	Advances in Cell Transplantation Therapy for Diseased Myocardium
title_short	Advances in Cell Transplantation Therapy for Diseased Myocardium
title_full	Advances in Cell Transplantation Therapy for Diseased Myocardium
title_fullStr	Advances in Cell Transplantation Therapy for Diseased Myocardium
title_full_unstemmed	Advances in Cell Transplantation Therapy for Diseased Myocardium
title_sort	advances in cell transplantation therapy for diseased myocardium
publisher	Hindawi Limited
series	Stem Cells International
issn	1687-966X 1687-9678
publishDate	2011-01-01
description	The overall objective of cell transplantation is to repopulate postinfarction scar with contractile cells, thus improving systolic function, and to prevent or to regress the remodeling process. Direct implantation of isolated myoblasts, cardiomyocytes, and bone-marrow-derived cells has shown prospect for improved cardiac performance in several animal models and patients suffering from heart failure. However, direct implantation of cultured cells can lead to major cell loss by leakage and cell death, inappropriate integration and proliferation, and cardiac arrhythmia. To resolve these problems an approach using 3-dimensional tissue-engineered cell constructs has been investigated. Cell engineering technology has enabled scaffold-free sheet development including generation of communication between cell graft and host tissue, creation of organized microvascular network, and relatively long-term survival after in vivo transplantation.
url	http://dx.doi.org/10.4061/2011/679171
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Advances in Cell Transplantation Therapy for Diseased Myocardium

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