Insulin treatment improves liver histopathology and decreases expression of inflammatory and fibrogenic genes in a hyperglycemic, dyslipidemic hamster model of NAFLD

Insulin treatment improves liver histopathology and decreases expression of inflammatory and fibrogenic genes in a hyperglycemic, dyslipidemic hamster model of NAFLD

Abstract Background Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are highly prevalent comorbidities in patients with Type 2 diabetes. While many of these patients eventually will need treatment with insulin, little is known about the effects of insulin treatment...

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Bibliographic Details
Main Authors: Victoria Svop Jensen, Christian Fledelius, Christina Zachodnik, Jesper Damgaard, Helle Nygaard, Kristina Steinicke Tornqvist, Rikke Kaae Kirk, Birgitte Martine Viuff, Erik Max Wulff, Jens Lykkesfeldt, Henning Hvid
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Journal of Translational Medicine
Subjects:
NAFLD
NASH
Non-alcoholic fatty liver disease
Non-alcoholic steatohepatitis
Animal models
Hamster
Online Access:https://doi.org/10.1186/s12967-021-02729-1

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