Signalling by CGRP and Adrenomedullin in the Cerebellum and Other Systems

Signalling by CGRP and Adrenomedullin in the Cerebellum and Other Systems

The best characterised signalling pathway activated by both CGRP and adrenomedullin is stimulation of adenylate cyclase via Gs. However, it is clear that in some circumstances the peptides can activate other signal transduction pathways, e.g., increases in intracellular calcium. Many of these signal...

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Main Authors: David Poyner, Heather Cater, Nick Hartell, Alex Conner, Debbie Hay, Steve Howitt, Dave Smith
Format: Article
Language:English
Published: Hindawi Limited 2001-01-01
Series:The Scientific World Journal
Online Access:http://dx.doi.org/10.1100/tsw.2001.434
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spelling doaj-08f8a31bb1dd47c398fb8619b08e788b2020-11-25T02:15:34ZengHindawi LimitedThe Scientific World Journal1537-744X2001-01-011111110.1100/tsw.2001.434Signalling by CGRP and Adrenomedullin in the Cerebellum and Other SystemsDavid Poyner0Heather Cater1Nick Hartell2Alex Conner3Debbie Hay4Steve Howitt5Dave Smith6Pharmaceutical Sciences Research Institute, Aston University, Birmingham, UKPharmaceutical Sciences Research Institute, Aston University, Birmingham, UKPharmaceutical Sciences Research Institute, Aston University, Birmingham, UKPharmaceutical Sciences Research Institute, Aston University, Birmingham, UKDepartment of Biosciences, University of Birmingham, Birmingham, UKPharmaceutical Sciences Research Institute, Aston University, Birmingham, UKDepartment of Biosciences, University of Birmingham, Birmingham, UKThe best characterised signalling pathway activated by both CGRP and adrenomedullin is stimulation of adenylate cyclase via Gs. However, it is clear that in some circumstances the peptides can activate other signal transduction pathways, e.g., increases in intracellular calcium. Many of these signalling pathways can be observed in cultured cells but it is important also to examine isolated tissues to discover the full repertoire of transduction events. In the rat cerebellum there are receptors that respond to both CGRP and adrenomedullin. These seem to be located postsynaptically on Parallel Fibre nerve terminals and modulate transmission to Purkinje cells. Adrenomedullin acts via cAMP, apparently to augment neurotransmitter release. By contrast, CGRP decreases transmitter release, via a non-cAMP mediated pathway. We are currently examining the role of NO and tyrosine kinases in the responses to these peptides.http://dx.doi.org/10.1100/tsw.2001.434
collection DOAJ
language English
format Article
sources DOAJ
author David Poyner
Heather Cater
Nick Hartell
Alex Conner
Debbie Hay
Steve Howitt
Dave Smith
spellingShingle David Poyner
Heather Cater
Nick Hartell
Alex Conner
Debbie Hay
Steve Howitt
Dave Smith
Signalling by CGRP and Adrenomedullin in the Cerebellum and Other Systems
The Scientific World Journal
author_facet David Poyner
Heather Cater
Nick Hartell
Alex Conner
Debbie Hay
Steve Howitt
Dave Smith
author_sort David Poyner
title Signalling by CGRP and Adrenomedullin in the Cerebellum and Other Systems
title_short Signalling by CGRP and Adrenomedullin in the Cerebellum and Other Systems
title_full Signalling by CGRP and Adrenomedullin in the Cerebellum and Other Systems
title_fullStr Signalling by CGRP and Adrenomedullin in the Cerebellum and Other Systems
title_full_unstemmed Signalling by CGRP and Adrenomedullin in the Cerebellum and Other Systems
title_sort signalling by cgrp and adrenomedullin in the cerebellum and other systems
publisher Hindawi Limited
series The Scientific World Journal
issn 1537-744X
publishDate 2001-01-01
description The best characterised signalling pathway activated by both CGRP and adrenomedullin is stimulation of adenylate cyclase via Gs. However, it is clear that in some circumstances the peptides can activate other signal transduction pathways, e.g., increases in intracellular calcium. Many of these signalling pathways can be observed in cultured cells but it is important also to examine isolated tissues to discover the full repertoire of transduction events. In the rat cerebellum there are receptors that respond to both CGRP and adrenomedullin. These seem to be located postsynaptically on Parallel Fibre nerve terminals and modulate transmission to Purkinje cells. Adrenomedullin acts via cAMP, apparently to augment neurotransmitter release. By contrast, CGRP decreases transmitter release, via a non-cAMP mediated pathway. We are currently examining the role of NO and tyrosine kinases in the responses to these peptides.
url http://dx.doi.org/10.1100/tsw.2001.434
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