Carbon Nano-Onions Reinforced Multilayered Thin Film System for Stimuli-Responsive Drug Release

• Main Authors: Narsimha Mamidi, Ramiro Manuel Velasco Delgadillo, Aldo Gonzáles Ortiz, Enrique V. Barrera
• Format: Article
• Language: English
• Published: MDPI AG 2020-12-01
• Series: Pharmaceutics
• Subjects: nanocomposite thin films; layer-by-layer assembly; strength; Young’s modulus; toughness; pH-responsive drug release
• Online Access: https://www.mdpi.com/1999-4923/12/12/1208

Herein, poly (<i>N</i>-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs) and anilinated-poly (ether ether ketone) (AN-PEEK) have synthesized, and AN-PEEK/f-CNOs composite thin films were primed via layer-by-layer (LbL) self-assembly for stimuli-responsive drug release. The obtained thin films exhibited pH-responsive drug release in a controlled manner; pH 4.5 = 99.2% and pH 6.5 = 59.3% of doxorubicin (DOX) release was observed over 15 days. Supramolecular π-π stacking interactions between f-CNOs and DOX played a critical role in controlling drug release from thin films. Cell viability was studied with human osteoblast cells and augmented viability was perceived. Moreover, the thin films presented 891.4 ± 8.2 MPa of the tensile strength (<inline-formula><math display="inline"><semantics><mrow><msub><mi>σ</mi><mrow><mi>u</mi><mi>l</mi><mi>t</mi></mrow></msub></mrow></semantics></math></inline-formula>), 43.2 ± 1.1 GPa of Young’s modulus (E), and 164.5 ± 1.7 Jg⁻¹ of toughness (K). Quantitative scrutiny revealed that the well-ordered aligned nanofibers provide critical interphase, and this could be responsible for augmented tensile properties. Nonetheless, a pH-responsive and mechanically robust biocompatible thin-film system may show potential applications in the biomedical field.