Role of microRNAs in hepatocellular carcinoma: a clinical perspective
Elisa Callegari,1 Bahaeldin K Elamin,1,2 Silvia Sabbioni,3,5 Laura Gramantieri,4 Massimo Negrini1,5 1Dipartimento di Morfologia, Chirurgia e Medicina Sperimentale, Università di Ferrara, Ferrara, Italy; 2Department of Microbiology, Faculty of Medical Laboratory Sciences, University of Kha...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Dove Medical Press
2013-09-01
|
Series: | OncoTargets and Therapy |
Online Access: | http://www.dovepress.com/role-of-micrornas-in-hepatocellular-carcinoma-a-clinical-perspective-a14239 |
id |
doaj-08eef3df533e4e3bb35b936d7ca2f25c |
---|---|
record_format |
Article |
spelling |
doaj-08eef3df533e4e3bb35b936d7ca2f25c2020-11-24T22:11:25ZengDove Medical PressOncoTargets and Therapy1178-69302013-09-012013default11671178Role of microRNAs in hepatocellular carcinoma: a clinical perspectiveCallegari EElamin BKSabbioni SGramantieri LNegrini MElisa Callegari,1 Bahaeldin K Elamin,1,2 Silvia Sabbioni,3,5 Laura Gramantieri,4 Massimo Negrini1,5 1Dipartimento di Morfologia, Chirurgia e Medicina Sperimentale, Università di Ferrara, Ferrara, Italy; 2Department of Microbiology, Faculty of Medical Laboratory Sciences, University of Khartoum, Sudan; 3Dipartimento di Scienze della Vita e Biotecnologie, Università di Ferrara, Ferrara, 4Centro di Ricerca Biomedica Applicata e Dipartimento di Medicina Interna, Policlinico S Orsola-Malpighi e Università di Bologna, Bologna, 5Tecnopolo "Laboratorio per le Tecnologie delle Terapie Avanzate", Università di Ferrara, Ferrara, Italy Abstract: Hepatocellular carcinoma (HCC) is one of the most deadly tumors, and current treatments for the disease are often ineffective. The discovery of the involvement of microRNAs (miRNAs) in hepatocarcinogenesis represents an important area of investigation for the development of their clinical applications. These molecules may act as oncogenes or tumor suppressors by directly or indirectly controlling the expression of key proteins involved in cancer-associated pathways. On the clinical side, because of their tumor-specific expression and stability in tissues and in the circulation, miRNAs have been proposed as novel diagnostic tools for classification and prognostic stratification of HCC. In recent years, the therapeutic potential of miRNAs has been demonstrated in various preclinical studies. Anti-miRNA oligonucleotides and miRNA mimics have been found to have antitumor activity. Moreover, by exploiting tumor-specific expression of miRNA, efforts have been aimed at improving targeting of tumor cells by replicative oncolytic viruses while sparing normal cells. These areas are expected to be explored further in the upcoming years to assess the clinical value of miRNA-based approaches in HCC and cancer in general. Keywords: hepatocellular carcinoma, microRNA, micromarkers, oncolytic viruseshttp://www.dovepress.com/role-of-micrornas-in-hepatocellular-carcinoma-a-clinical-perspective-a14239 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Callegari E Elamin BK Sabbioni S Gramantieri L Negrini M |
spellingShingle |
Callegari E Elamin BK Sabbioni S Gramantieri L Negrini M Role of microRNAs in hepatocellular carcinoma: a clinical perspective OncoTargets and Therapy |
author_facet |
Callegari E Elamin BK Sabbioni S Gramantieri L Negrini M |
author_sort |
Callegari E |
title |
Role of microRNAs in hepatocellular carcinoma: a clinical perspective |
title_short |
Role of microRNAs in hepatocellular carcinoma: a clinical perspective |
title_full |
Role of microRNAs in hepatocellular carcinoma: a clinical perspective |
title_fullStr |
Role of microRNAs in hepatocellular carcinoma: a clinical perspective |
title_full_unstemmed |
Role of microRNAs in hepatocellular carcinoma: a clinical perspective |
title_sort |
role of micrornas in hepatocellular carcinoma: a clinical perspective |
publisher |
Dove Medical Press |
series |
OncoTargets and Therapy |
issn |
1178-6930 |
publishDate |
2013-09-01 |
description |
Elisa Callegari,1 Bahaeldin K Elamin,1,2 Silvia Sabbioni,3,5 Laura Gramantieri,4 Massimo Negrini1,5 1Dipartimento di Morfologia, Chirurgia e Medicina Sperimentale, Università di Ferrara, Ferrara, Italy; 2Department of Microbiology, Faculty of Medical Laboratory Sciences, University of Khartoum, Sudan; 3Dipartimento di Scienze della Vita e Biotecnologie, Università di Ferrara, Ferrara, 4Centro di Ricerca Biomedica Applicata e Dipartimento di Medicina Interna, Policlinico S Orsola-Malpighi e Università di Bologna, Bologna, 5Tecnopolo "Laboratorio per le Tecnologie delle Terapie Avanzate", Università di Ferrara, Ferrara, Italy Abstract: Hepatocellular carcinoma (HCC) is one of the most deadly tumors, and current treatments for the disease are often ineffective. The discovery of the involvement of microRNAs (miRNAs) in hepatocarcinogenesis represents an important area of investigation for the development of their clinical applications. These molecules may act as oncogenes or tumor suppressors by directly or indirectly controlling the expression of key proteins involved in cancer-associated pathways. On the clinical side, because of their tumor-specific expression and stability in tissues and in the circulation, miRNAs have been proposed as novel diagnostic tools for classification and prognostic stratification of HCC. In recent years, the therapeutic potential of miRNAs has been demonstrated in various preclinical studies. Anti-miRNA oligonucleotides and miRNA mimics have been found to have antitumor activity. Moreover, by exploiting tumor-specific expression of miRNA, efforts have been aimed at improving targeting of tumor cells by replicative oncolytic viruses while sparing normal cells. These areas are expected to be explored further in the upcoming years to assess the clinical value of miRNA-based approaches in HCC and cancer in general. Keywords: hepatocellular carcinoma, microRNA, micromarkers, oncolytic viruses |
url |
http://www.dovepress.com/role-of-micrornas-in-hepatocellular-carcinoma-a-clinical-perspective-a14239 |
work_keys_str_mv |
AT callegarie roleofmicrornasinhepatocellularcarcinomaaclinicalperspective AT elaminbk roleofmicrornasinhepatocellularcarcinomaaclinicalperspective AT sabbionis roleofmicrornasinhepatocellularcarcinomaaclinicalperspective AT gramantieril roleofmicrornasinhepatocellularcarcinomaaclinicalperspective AT negrinim roleofmicrornasinhepatocellularcarcinomaaclinicalperspective |
_version_ |
1725805768430583808 |