Role of microRNAs in hepatocellular carcinoma: a clinical perspective

Elisa Callegari,1 Bahaeldin K Elamin,1,2 Silvia Sabbioni,3,5 Laura Gramantieri,4 Massimo Negrini1,5 1Dipartimento di Morfologia, Chirurgia e Medicina Sperimentale, Università di Ferrara, Ferrara, Italy; 2Department of Microbiology, Faculty of Medical Laboratory Sciences, University of Kha...

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Main Authors: Callegari E, Elamin BK, Sabbioni S, Gramantieri L, Negrini M
Format: Article
Language:English
Published: Dove Medical Press 2013-09-01
Series:OncoTargets and Therapy
Online Access:http://www.dovepress.com/role-of-micrornas-in-hepatocellular-carcinoma-a-clinical-perspective-a14239
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spelling doaj-08eef3df533e4e3bb35b936d7ca2f25c2020-11-24T22:11:25ZengDove Medical PressOncoTargets and Therapy1178-69302013-09-012013default11671178Role of microRNAs in hepatocellular carcinoma: a clinical perspectiveCallegari EElamin BKSabbioni SGramantieri LNegrini MElisa Callegari,1 Bahaeldin K Elamin,1,2 Silvia Sabbioni,3,5 Laura Gramantieri,4 Massimo Negrini1,5 1Dipartimento di Morfologia, Chirurgia e Medicina Sperimentale, Università di Ferrara, Ferrara, Italy; 2Department of Microbiology, Faculty of Medical Laboratory Sciences, University of Khartoum, Sudan; 3Dipartimento di Scienze della Vita e Biotecnologie, Università di Ferrara, Ferrara, 4Centro di Ricerca Biomedica Applicata e Dipartimento di Medicina Interna, Policlinico S Orsola-Malpighi e Università di Bologna, Bologna, 5Tecnopolo "Laboratorio per le Tecnologie delle Terapie Avanzate", Università di Ferrara, Ferrara, Italy Abstract: Hepatocellular carcinoma (HCC) is one of the most deadly tumors, and current treatments for the disease are often ineffective. The discovery of the involvement of microRNAs (miRNAs) in hepatocarcinogenesis represents an important area of investigation for the development of their clinical applications. These molecules may act as oncogenes or tumor suppressors by directly or indirectly controlling the expression of key proteins involved in cancer-associated pathways. On the clinical side, because of their tumor-specific expression and stability in tissues and in the circulation, miRNAs have been proposed as novel diagnostic tools for classification and prognostic stratification of HCC. In recent years, the therapeutic potential of miRNAs has been demonstrated in various preclinical studies. Anti-miRNA oligonucleotides and miRNA mimics have been found to have antitumor activity. Moreover, by exploiting tumor-specific expression of miRNA, efforts have been aimed at improving targeting of tumor cells by replicative oncolytic viruses while sparing normal cells. These areas are expected to be explored further in the upcoming years to assess the clinical value of miRNA-based approaches in HCC and cancer in general. Keywords: hepatocellular carcinoma, microRNA, micromarkers, oncolytic viruseshttp://www.dovepress.com/role-of-micrornas-in-hepatocellular-carcinoma-a-clinical-perspective-a14239
collection DOAJ
language English
format Article
sources DOAJ
author Callegari E
Elamin BK
Sabbioni S
Gramantieri L
Negrini M
spellingShingle Callegari E
Elamin BK
Sabbioni S
Gramantieri L
Negrini M
Role of microRNAs in hepatocellular carcinoma: a clinical perspective
OncoTargets and Therapy
author_facet Callegari E
Elamin BK
Sabbioni S
Gramantieri L
Negrini M
author_sort Callegari E
title Role of microRNAs in hepatocellular carcinoma: a clinical perspective
title_short Role of microRNAs in hepatocellular carcinoma: a clinical perspective
title_full Role of microRNAs in hepatocellular carcinoma: a clinical perspective
title_fullStr Role of microRNAs in hepatocellular carcinoma: a clinical perspective
title_full_unstemmed Role of microRNAs in hepatocellular carcinoma: a clinical perspective
title_sort role of micrornas in hepatocellular carcinoma: a clinical perspective
publisher Dove Medical Press
series OncoTargets and Therapy
issn 1178-6930
publishDate 2013-09-01
description Elisa Callegari,1 Bahaeldin K Elamin,1,2 Silvia Sabbioni,3,5 Laura Gramantieri,4 Massimo Negrini1,5 1Dipartimento di Morfologia, Chirurgia e Medicina Sperimentale, Università di Ferrara, Ferrara, Italy; 2Department of Microbiology, Faculty of Medical Laboratory Sciences, University of Khartoum, Sudan; 3Dipartimento di Scienze della Vita e Biotecnologie, Università di Ferrara, Ferrara, 4Centro di Ricerca Biomedica Applicata e Dipartimento di Medicina Interna, Policlinico S Orsola-Malpighi e Università di Bologna, Bologna, 5Tecnopolo "Laboratorio per le Tecnologie delle Terapie Avanzate", Università di Ferrara, Ferrara, Italy Abstract: Hepatocellular carcinoma (HCC) is one of the most deadly tumors, and current treatments for the disease are often ineffective. The discovery of the involvement of microRNAs (miRNAs) in hepatocarcinogenesis represents an important area of investigation for the development of their clinical applications. These molecules may act as oncogenes or tumor suppressors by directly or indirectly controlling the expression of key proteins involved in cancer-associated pathways. On the clinical side, because of their tumor-specific expression and stability in tissues and in the circulation, miRNAs have been proposed as novel diagnostic tools for classification and prognostic stratification of HCC. In recent years, the therapeutic potential of miRNAs has been demonstrated in various preclinical studies. Anti-miRNA oligonucleotides and miRNA mimics have been found to have antitumor activity. Moreover, by exploiting tumor-specific expression of miRNA, efforts have been aimed at improving targeting of tumor cells by replicative oncolytic viruses while sparing normal cells. These areas are expected to be explored further in the upcoming years to assess the clinical value of miRNA-based approaches in HCC and cancer in general. Keywords: hepatocellular carcinoma, microRNA, micromarkers, oncolytic viruses
url http://www.dovepress.com/role-of-micrornas-in-hepatocellular-carcinoma-a-clinical-perspective-a14239
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