Giant Bilateral Renal Angiomyolipomas and Lymphangioleiomyomatosis Presenting after Two Successive Pregnancies Successfully Treated with Surgery and Rapamycin

Giant Bilateral Renal Angiomyolipomas and Lymphangioleiomyomatosis Presenting after Two Successive Pregnancies Successfully Treated with Surgery and Rapamycin

We report the case of a 25-year-old woman who presented with abdominal and flank pain with two successive pregnancies and was diagnosed of giant bilateral renal AMLs and pulmonary LAM associated with TSC in the post-partum of her second pregnancy. This case illustrates that in women with TSC rapid g...

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Main Authors: Ramón Peces, Emilio Cuesta-López, Carlos Peces, Rafael Selgas
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:The Scientific World Journal
Online Access:http://dx.doi.org/10.1100/2011/263137
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spelling doaj-08e2ea67f370406b947de275849ed7fd2020-11-25T02:16:48ZengHindawi LimitedThe Scientific World Journal1537-744X2011-01-01112115212310.1100/2011/263137263137Giant Bilateral Renal Angiomyolipomas and Lymphangioleiomyomatosis Presenting after Two Successive Pregnancies Successfully Treated with Surgery and RapamycinRamón Peces0Emilio Cuesta-López1Carlos Peces2Rafael Selgas3Servicio de Nefrología, Hospital Universitario La Paz, IdiPAZ, 28046 Madrid, SpainServicio de Radiología, Hospital Universitario La Paz, 28046 Madrid, SpainArea de Tecnología de la Información, SESCAM, 45071 Toledo, SpainServicio de Nefrología, Hospital Universitario La Paz, IdiPAZ, 28046 Madrid, SpainWe report the case of a 25-year-old woman who presented with abdominal and flank pain with two successive pregnancies and was diagnosed of giant bilateral renal AMLs and pulmonary LAM associated with TSC in the post-partum of her second pregnancy. This case illustrates that in women with TSC rapid growth from renal AMLs and development of LAM may occur with successive pregnancies. It also stresses the potential for preservation of renal function despite successive bilateral renal surgery of giant AMLs. Moreover, the treatment with a low-dose rapamycin may be an option for LAM treatment. Finally, a low-dose rapamycin may be considered as an adjuvant treatment together to kidney-sparing conservative surgery for renal AMLs.http://dx.doi.org/10.1100/2011/263137
collection DOAJ
language English
format Article
sources DOAJ
author Ramón Peces
Emilio Cuesta-López
Carlos Peces
Rafael Selgas
spellingShingle Ramón Peces
Emilio Cuesta-López
Carlos Peces
Rafael Selgas
Giant Bilateral Renal Angiomyolipomas and Lymphangioleiomyomatosis Presenting after Two Successive Pregnancies Successfully Treated with Surgery and Rapamycin
The Scientific World Journal
author_facet Ramón Peces
Emilio Cuesta-López
Carlos Peces
Rafael Selgas
author_sort Ramón Peces
title Giant Bilateral Renal Angiomyolipomas and Lymphangioleiomyomatosis Presenting after Two Successive Pregnancies Successfully Treated with Surgery and Rapamycin
title_short Giant Bilateral Renal Angiomyolipomas and Lymphangioleiomyomatosis Presenting after Two Successive Pregnancies Successfully Treated with Surgery and Rapamycin
title_full Giant Bilateral Renal Angiomyolipomas and Lymphangioleiomyomatosis Presenting after Two Successive Pregnancies Successfully Treated with Surgery and Rapamycin
title_fullStr Giant Bilateral Renal Angiomyolipomas and Lymphangioleiomyomatosis Presenting after Two Successive Pregnancies Successfully Treated with Surgery and Rapamycin
title_full_unstemmed Giant Bilateral Renal Angiomyolipomas and Lymphangioleiomyomatosis Presenting after Two Successive Pregnancies Successfully Treated with Surgery and Rapamycin
title_sort giant bilateral renal angiomyolipomas and lymphangioleiomyomatosis presenting after two successive pregnancies successfully treated with surgery and rapamycin
publisher Hindawi Limited
series The Scientific World Journal
issn 1537-744X
publishDate 2011-01-01
description We report the case of a 25-year-old woman who presented with abdominal and flank pain with two successive pregnancies and was diagnosed of giant bilateral renal AMLs and pulmonary LAM associated with TSC in the post-partum of her second pregnancy. This case illustrates that in women with TSC rapid growth from renal AMLs and development of LAM may occur with successive pregnancies. It also stresses the potential for preservation of renal function despite successive bilateral renal surgery of giant AMLs. Moreover, the treatment with a low-dose rapamycin may be an option for LAM treatment. Finally, a low-dose rapamycin may be considered as an adjuvant treatment together to kidney-sparing conservative surgery for renal AMLs.
url http://dx.doi.org/10.1100/2011/263137
work_keys_str_mv AT ramonpeces giantbilateralrenalangiomyolipomasandlymphangioleiomyomatosispresentingaftertwosuccessivepregnanciessuccessfullytreatedwithsurgeryandrapamycin
AT emiliocuestalopez giantbilateralrenalangiomyolipomasandlymphangioleiomyomatosispresentingaftertwosuccessivepregnanciessuccessfullytreatedwithsurgeryandrapamycin
AT carlospeces giantbilateralrenalangiomyolipomasandlymphangioleiomyomatosispresentingaftertwosuccessivepregnanciessuccessfullytreatedwithsurgeryandrapamycin
AT rafaelselgas giantbilateralrenalangiomyolipomasandlymphangioleiomyomatosispresentingaftertwosuccessivepregnanciessuccessfullytreatedwithsurgeryandrapamycin
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