Relation of bleeding patterns and factor VIII levels in children with hemophilia

• Main Authors: Rina Rahardiani, H. S. Moeslichan MZ, Agus Firmansyah
• Format: Article
• Language: English
• Published: Indonesian Pediatric Society Publishing House 2016-10-01
• Series: Paediatrica Indonesiana
• Subjects: hemophilia A; bleeding patterns; hemophilia classification
• Online Access: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/921

Background The high costs of factor VIII examination cause the delay in the diagnosis of hemophilia A; consequently many pa- tients do not receive adequate therapy which results in failure to survive into adulthood or survive with creeple. Objective To determine bleeding patterns of hemophilia A pa- tients for the prediction of its classification. Methods We perform retrospective analysis of hemophilia patients at the Integrated Service Center of Hemophilia, Cipto Mangun- kusumo Hospital, Jakarta. Results Family history, age at the first bleeding, frequency of bleed- ing, and factor VIII examination can significantly differentiate the classification of hemophilia A (P=0.015; 0.014; <0.0001; and <0.0001, respectively) while age groups, triggering trauma for the first bleeding, type of the first bleeding, history of previous trauma, the most frequent type of bleeding, age at diagnosis, and con- sumption of cryoprecipitate cannot. (P=0.985; 0.475; 0.342; 0.318; 0.058; 0.477; and 0.547, respectively). Conclusion Age at first bleeding, frequency of bleeding, and fam- ily history can be used to predict classification of hemophilia A.