Explicit kinetic heterogeneity: mathematical models for interpretation of deuterium labeling of heterogeneous cell populations.

Estimation of division and death rates of lymphocytes in different conditions is vital for quantitative understanding of the immune system. Deuterium, in the form of deuterated glucose or heavy water, can be used to measure rates of proliferation and death of lymphocytes in vivo. Inferring these rat...

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Bibliographic Details
Main Authors: Vitaly V Ganusov, José A M Borghans, Rob J De Boer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-02-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC2816685?pdf=render