Nanometer-Scale Pores: Potential Applications for Analyte Detection and DNA Characterization

Nanometer-Scale Pores: Potential Applications for Analyte Detection and DNA Characterization

Several classes of transmembrane protein ion channels function in vivo as sensitive and selective detection elements for analytes. Recent studies on single channels reconstituted into planar lipid bilayer membranes suggest that nanometer-scale pores can be used to detect, quantitate and characterize...

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Main Author: John J. Kasianowicz
Format: Article
Language:English
Published: Hindawi Limited 2002-01-01
Series:Disease Markers
Online Access:http://dx.doi.org/10.1155/2002/565204
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spelling doaj-08ad26c0a5594d3a8e526cfaf9e73a1c2020-11-24T21:55:29ZengHindawi LimitedDisease Markers0278-02401875-86302002-01-0118418519110.1155/2002/565204Nanometer-Scale Pores: Potential Applications for Analyte Detection and DNA CharacterizationJohn J. Kasianowicz0National Institute of Standards and Technology, Gaithersburg, MD 20899-8313, USASeveral classes of transmembrane protein ion channels function in vivo as sensitive and selective detection elements for analytes. Recent studies on single channels reconstituted into planar lipid bilayer membranes suggest that nanometer-scale pores can be used to detect, quantitate and characterize a wide range of analytes that includes small ions and single stranded DNA. We briefly review here these studies and identify leaps in technology that, if realized, might lead to innovations for the early detection of cancer.http://dx.doi.org/10.1155/2002/565204
collection DOAJ
language English
format Article
sources DOAJ
author John J. Kasianowicz
spellingShingle John J. Kasianowicz
Nanometer-Scale Pores: Potential Applications for Analyte Detection and DNA Characterization
Disease Markers
author_facet John J. Kasianowicz
author_sort John J. Kasianowicz
title Nanometer-Scale Pores: Potential Applications for Analyte Detection and DNA Characterization
title_short Nanometer-Scale Pores: Potential Applications for Analyte Detection and DNA Characterization
title_full Nanometer-Scale Pores: Potential Applications for Analyte Detection and DNA Characterization
title_fullStr Nanometer-Scale Pores: Potential Applications for Analyte Detection and DNA Characterization
title_full_unstemmed Nanometer-Scale Pores: Potential Applications for Analyte Detection and DNA Characterization
title_sort nanometer-scale pores: potential applications for analyte detection and dna characterization
publisher Hindawi Limited
series Disease Markers
issn 0278-0240
1875-8630
publishDate 2002-01-01
description Several classes of transmembrane protein ion channels function in vivo as sensitive and selective detection elements for analytes. Recent studies on single channels reconstituted into planar lipid bilayer membranes suggest that nanometer-scale pores can be used to detect, quantitate and characterize a wide range of analytes that includes small ions and single stranded DNA. We briefly review here these studies and identify leaps in technology that, if realized, might lead to innovations for the early detection of cancer.
url http://dx.doi.org/10.1155/2002/565204
work_keys_str_mv AT johnjkasianowicz nanometerscaleporespotentialapplicationsforanalytedetectionanddnacharacterization
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