Deregulated expression of A1, Bcl-2, Bcl-xL, and Mcl-1 antiapoptotic proteins and Bid, Bad, and Bax proapoptotic genes in polycythemia vera patients

Deregulated expression of A1, Bcl-2, Bcl-xL, and Mcl-1 antiapoptotic proteins and Bid, Bad, and Bax proapoptotic genes in polycythemia vera patients

Apoptosis deregulation might have a role in the pathophysiology of polycythemia vera (PV). This study evaluated Bcl-2 molecule expression in CD34+ cells and leukocytes in 12 PV patients. Gene expression was investigated by real time PCR using SybrGreen Quantitect kit and protein expression was evalu...

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Bibliographic Details
Main Authors: Elainy Patricia Lino Gasparotto, Raquel Tognon, Aline Fernanda Ferreira, Gislane Lelis Vilela Oliveira, Patrícia Vianna Bonini Palma, Maria Aparecida Zanichelli, Elizabeth Xisto Souto, Carlos Eduardo Engel Velano, Belinda Pinto Simões, Rita de Cassia Viu Carrara, Simone Kashima, Dimas Tadeu Covas, Fabíola Attie de Castro, Ana Maria de Souza
Format: Article
Language:English
Published: Universidade de São Paulo 2011-12-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Policitemia vera
Mutação gênica
Expressão gênica
Apoptose
Membros da Família Bcl-2
Polycythemia vera
Gene mutation
Gene expression
Apoptosis
Bcl-2 family members
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000400025

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000400025

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