Study on the effect of clopidogrel combined with ezetimibe in the treatment of cerebral infarction

• Main Author: Kang Zhao
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2019-10-01
• Series: Journal of Hainan Medical University
• Subjects: clopidogrel; ezetimibe; cerebral infarction; effectiveness; safety
• Online Access: http://www.hnykdxxb.com/PDF/201910/11.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To investigate the effect of clopidogrel combined with ezetimibe on cerebral infarction. Methods: 110 patients with acute cerebral infarction treated in our hospital from January 2016 to December 2018 were selected as study object. The clinical case data were retrospectively analyzed. According to different treatment options, they were divided into the observation group (using clopidogrel combined with ezetimibe, n=41), the control group 1 (treated with clopidogrel, n=39) and the control group 2 (using clopidogrel combined with atorvastatin, n=30). Finally, the serum levels of folic acid (FA), ferritin, troponin I (cTnI), the blood lipid levels of high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglyceride (TG) and internal carotid artery intima-media thickness (IMT) of three groups were compared. The National Institutes of Health Stroke Scale (NIHSS) score, Barthel score and efficacy of three groups were compared. Results: (1) There were no significant differences in the serum levels( FA, ferritin cTnI), the serum lipid levels (HDL-C, LDL-C, TC, TG), IMT, NIHSS scores, and Barthel scores between three groups (P>0.05).mAfter treatment, the FA and HDL-C values of control group 2 were higher than those of the control group 1 (P<0.05), and the observation group increased significantly compared with control group 2 (P<0.05). In addition, the levels of ferritin, cTnI, LDL-C, TC, TG, IMT, NIHSS score and Barthel score in the control group 2 were lower than those in the control group 1 (P<0.05), and the observation group was more significant than the control group 2 (P<0.05). (2) In terms of treatment efficiency, the observation group was the highest, the control group was 2 was the second, and the control group 1 was the lowest (P<0.05); (3) There was no significant difference among three groups (P>0.05). Conclusions: The combination of clopidogrel and ezetimibe in the treatment of cerebral infarction can effectively improve the blood lipid level, promote the metabolism of nerve function and reduce the formation of plaque. This program is safe and effective and worth recommending.