Dietary serine-microbiota interaction enhances chemotherapeutic toxicity without altering drug conversion
The gut microbiota can alter the effects of anticancer fluoropyrimidines such as 5-fluorodeoxyuridine (FUdR) in the model organism C. elegans. Here, the authors show that these effects are further affected by diet, and dietary thymidine and serine increase FUdR toxicity in C. elegans via different m...
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Bibliographic Details
| Main Authors: |
Wenfan Ke,
James A. Saba,
Cong-Hui Yao,
Michael A. Hilzendeger,
Anna Drangowska-Way,
Chintan Joshi,
Vinod K. Mony,
Shawna B. Benjamin,
Sisi Zhang,
Jason Locasale,
Gary J. Patti,
Nathan Lewis,
Eyleen J. O’Rourke |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2020-05-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-16220-w
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