Enhanced exosome secretion in Down syndrome brain - a protective mechanism to alleviate neuronal endosomal abnormalities

Enhanced exosome secretion in Down syndrome brain - a protective mechanism to alleviate neuronal endosomal abnormalities

Abstract A dysfunctional endosomal pathway and abnormally enlarged early endosomes in neurons are an early characteristic of Down syndrome (DS) and Alzheimer’s disease (AD). We have hypothesized that endosomal material can be released by endosomal multivesicular bodies (MVBs) into the extracellular...

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Bibliographic Details
Main Authors: Sébastien A. Gauthier, Rocío Pérez-González, Ajay Sharma, Fang-Ke Huang, Melissa J. Alldred, Monika Pawlik, Gurjinder Kaur, Stephen D. Ginsberg, Thomas A. Neubert, Efrat Levy
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Acta Neuropathologica Communications
Subjects:
Down syndrome
endosome
extracellular vesicle
exosome
CD63
rab35
Online Access:http://link.springer.com/article/10.1186/s40478-017-0466-0

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