Co-delivery of doxorubicin, docosahexaenoic acid, and α-tocopherol succinate by nanostructured lipid carriers has a synergistic effect to enhance antitumor activity and reduce toxicity

Co-delivery of doxorubicin, docosahexaenoic acid, and α-tocopherol succinate by nanostructured lipid carriers has a synergistic effect to enhance antitumor activity and reduce toxicity

Doxorubicin (DOX) is widely used in cancer treatment, however, its use is often limited due to its side effects. To avoid these shortcomings, the encapsulation of DOX into nanocarriers has been suggested. Herein, we proposed a novel nanostructured lipid carrier (NLC) formulation loading DOX, docosah...

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Bibliographic Details
Main Authors: Eduardo Burgarelli Lages, Renata Salgado Fernandes, Juliana de Oliveira Silva, Ângelo Malachias de Souza, Geovanni Dantas Cassali, André Luís Branco de Barros, Lucas Antônio Miranda Ferreira
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Doxorubicin
Combination therapy
Ion-pairing
Synergism
Antitumor activity
Cardiotoxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220310684

Internet

http://www.sciencedirect.com/science/article/pii/S0753332220310684

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