A Protein Aggregation Inhibitor, Leuco-Methylthioninium Bis(Hydromethanesulfonate), Decreases α-Synuclein Inclusions in a Transgenic Mouse Model of Synucleinopathy

A Protein Aggregation Inhibitor, Leuco-Methylthioninium Bis(Hydromethanesulfonate), Decreases α-Synuclein Inclusions in a Transgenic Mouse Model of Synucleinopathy

α-Synuclein (α-Syn) aggregation is a pathological feature of synucleinopathies, neurodegenerative disorders that include Parkinson’s disease (PD). We have tested whether N,N,N′,N′-tetramethyl-10H-phenothiazine-3,7-diaminium bis(hydromethanesulfonate) (leuco-methylthioninium bis(hydromethanesulfonate...

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Bibliographic Details
Main Authors: Karima Schwab, Silke Frahm, David Horsley, Janet E. Rickard, Valeria Melis, Elizabeth A. Goatman, Mandy Magbagbeolu, Morag Douglas, Michael G. Leith, Thomas C. Baddeley, John M. D. Storey, Gernot Riedel, Claude M. Wischik, Charles R. Harrington, Franz Theuring
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Molecular Neuroscience
Subjects:
aggregation inhibitor
leucomethylthioninium
mouse model
Parkinson’s disease
α-synuclein
synucleinopathy
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00447/full

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http://journal.frontiersin.org/article/10.3389/fnmol.2017.00447/full

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