rs953413 Regulates Polyunsaturated Fatty Acid Metabolism by Modulating ELOVL2 Expression

rs953413 Regulates Polyunsaturated Fatty Acid Metabolism by Modulating ELOVL2 Expression

Summary: Long-chain polyunsaturated fatty acids (LC-PUFAs) influence human health in several areas, including cardiovascular disease, diabetes, fatty liver disease, and cancer. ELOVL2 encodes one of the key enzymes in the in vivo synthesis of LC-PUFAs from their precursors. Variants near ELOVL2 have...

Full description

Bibliographic Details
Main Authors:	Gang Pan, Marco Cavalli, Björn Carlsson, Stanko Skrtic, Chanchal Kumar, Claes Wadelius
Format:	Article
Language:	English
Published:	Elsevier 2020-02-01
Series:	iScience
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004219305541

Similar Items

DHA intake interacts with ELOVL2 and ELOVL5 genetic variants to influence polyunsaturated fatty acids in human milk
by: Yixia Wu霞吴义, et al.
Published: (2019-05-01)

Regulation of Elovl and fatty acid metabolism
by: Brolinson, Annelie
Published: (2009)

Polyunsaturated fatty acid elongation and desaturation in activated human T-cells: ELOVL5 is the key elongase
by: Philippe-Pierre Robichaud, et al.
Published: (2018-12-01)

Studies of liver tissue identify functional gene regulatory elements associated to gene expression, type 2 diabetes, and other metabolic diseases
by: Marco Cavalli, et al.
Published: (2019-04-01)

Estrogen Enhances the Expression of the Polyunsaturated Fatty Acid Elongase Elovl2 via ERα in Breast Cancer Cells.
by: Amanda González-Bengtsson, et al.
Published: (2016-01-01)

Estrogen Promotes Hepatic Synthesis of Long-Chain Polyunsaturated Fatty Acids by Regulating ELOVL5 at Post-Transcriptional Level in Laying Hens
by: Meng Zhang, et al.
Published: (2017-06-01)

Effects of <i>ELOVL4</i> gene overexpress on the synthesis efficiency of n3 and n6 very long chain polyunsaturated fatty acids
by: Man Yu, et al.
Published: (2014-08-01)

Single Nucleotide Polymorphisms in the FADS Gene Cluster but not the ELOVL2 Gene are Associated with Serum Polyunsaturated Fatty Acid Composition and Development of Allergy (in a Swedish Birth Cohort)
by: Malin Barman, et al.
Published: (2015-12-01)

Molecular basis for differential elongation of omega-3 docosapentaenoic acid by the rat Elovl5 and Elovl2[S]
by: Melissa K. Gregory, et al.
Published: (2013-10-01)

Gene expression of desaturase (FADS1 and FADS2) and Elongase (ELOVL5) enzymes in peripheral blood: association with polyunsaturated fatty acid levels and atopic eczema in 4-year-old children.
by: Aida Maribel Chisaguano, et al.
Published: (2013-01-01)

Cytochrome P450 Metabolism of Polyunsaturated Fatty Acids and Neurodegeneration
by: Morteza Sarparast, et al.
Published: (2020-11-01)

Long-Chain Polyunsaturated Fatty Acids in Inborn Errors of Metabolism
by: Katalin Fekete, et al.
Published: (2010-09-01)

Polyunsaturated Fatty Acids, Phytosterols and Cholesterol Metabolism in the Mediterranean Diet
by: Zdeněk Zadák, et al.
Published: (2006-01-01)

MICROBIAL METABOLISM AND PRODUCTION OF C-20 POLYUNSATURATED FATTY ACIDS
by: Kawasima, Hiroshi
Published: (2015)

Studies on the metabolic fate of n-3 polyunsaturated fatty acids
by: Sacha Ferdinandusse, et al.
Published: (2003-10-01)

Influence of Single Nucleotide Polymorphisms of ELOVL on Biomarkers of Metabolic Alterations in the Mexican Population
by: María Luisa Maycotte-Cervantes, et al.
Published: (2020-11-01)

Effects of ELOVL6 on Liver Cancer
by: Yaw-ShengHuang, et al.
Published: (2010)

Endoplasmic reticulum microenvironment and conserved histidines govern ELOVL4 fatty acid elongase activity
by: Sreemathi Logan, et al.
Published: (2014-04-01)

Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice*[S]
by: Young-Ah Moon, et al.
Published: (2009-03-01)

Seawater Culture Increases Omega-3 Long-Chain Polyunsaturated Fatty Acids (N-3 LC-PUFA) Levels in Japanese Sea Bass (<i>Lateolabrax japonicus</i>), Probably by Upregulating Elovl5
by: Xiaojing Dong, et al.
Published: (2020-09-01)

The role of polyunsaturated fatty acid metabolism in overweight and obese children and adolescents
by: A. A. Glazyrina, et al.
Published: (2016-03-01)

Dietary polyunsaturated fatty acids and the metabolic syndrome in UK Indian Asians
by: Brady, Louise
Published: (2003)

Polyunsaturated fatty acids regulate pig lipid metabolism by transcription factor
by: Je-Ming Hsu, et al.
Published: (2002)

Polyunsaturated fatty acid metabolism in retinal and cerebral microvascular endothelial cells.
by: I Delton-Vandenbroucke, et al.
Published: (1997-01-01)

Polymorphism in the ELOVL6 gene is associated with a major QTL effect on fatty acid composition in pigs.
by: Jordi Corominas, et al.
Published: (2013-01-01)

Novel Cellular Functions of Very Long Chain-Fatty Acids: Insight From ELOVL4 Mutations
by: Ferenc Deák, et al.
Published: (2019-09-01)

Association of maternal weight with FADS and ELOVL genetic variants and fatty acid levels- The PREOBE follow-up.
by: Andrea de la Garza Puentes, et al.
Published: (2017-01-01)

ELOVL5-Mediated Long Chain Fatty Acid Elongation Contributes to Enzalutamide Resistance of Prostate Cancer
by: Huan Xu, et al.
Published: (2021-08-01)

Modulation of polyunsaturated fatty acid metabolism in human umbilical vein endothelial cell cultures by antioxidants
by: Khaza'ai, Huzwah
Published: (1997)

ELOVL2: Not just a biomarker of aging
by: Daniel L. Chao, et al.
Published: (2020-01-01)

Polyunsaturated fatty acids in mitochondria
by: T. Richardson, et al.
Published: (1962-07-01)

Polyunsaturated fatty acids and inflammation
by: Calder Philip C.
Published: (2004-01-01)

Polyunsaturated Fatty Acids as Modulators of KV7 Channels
by: Johan E. Larsson, et al.
Published: (2020-06-01)

Functional characterization and differential nutritional regulation of putative Elovl5 and Elovl4 elongases in large yellow croaker (Larimichthys crocea)
by: Songlin Li, et al.
Published: (2017-05-01)

Supplementation with N-3 long-chain polyunsaturated fatty acids or olive oil in men and women with renal disease induces differential changes in the DNA methylation of FADS2 and ELOVL5 in peripheral blood mononuclear cells.
by: Samuel P Hoile, et al.
Published: (2014-01-01)

Supplementation with n-3 long-chain polyunsaturated fatty acids or olive oil in men and women with renal disease induces differential changes in the DNA methylation of FADS2 and ELOVL5 in peripheral blood mononuclear cells
by: Hoile, Samuel P., et al.
Published: (2014)

ELOVL6 genetic variation is related to insulin sensitivity: a new candidate gene in energy metabolism.
by: Sonsoles Morcillo, et al.
Published: (2011-01-01)

The Role of Omega-3 Polyunsaturated Fatty Acids in Stroke
by: Jiyuan Bu, et al.
Published: (2016-01-01)

Deletion of ELOVL6 blocks the synthesis of oleic acid but does not prevent the development of fatty liver or insulin resistance[S]
by: Young-Ah Moon, et al.
Published: (2014-12-01)

Evolution and Functional Characteristics of the Novel <i>elovl8</i> That Play Pivotal Roles in Fatty Acid Biosynthesis
by: Shouxiang Sun, et al.
Published: (2021-08-01)