Uncoupling of T Cell Receptor Zeta Chain Function during the Induction of Anergy by the Superantigen, Staphylococcal Enterotoxin A

Uncoupling of T Cell Receptor Zeta Chain Function during the Induction of Anergy by the Superantigen, Staphylococcal Enterotoxin A

Staphylococcus aureus enterotoxins have immunomodulatory properties. In this study, we show that Staphylococcal enterotoxin A (SEA) induces a strong proliferative response in a murine T cell clone independent of MHC class II bearing cells. SEA stimulation also induces a state of hypo-responsiveness...

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Bibliographic Details
Main Authors: William D. Cornwell, Thomas J. Rogers
Format: Article
Language:English
Published: MDPI AG 2010-06-01
Series:Toxins
Subjects:
superantigen
Staphylococcus aureus
SEA
anergy
zeta chain
enterotoxin
Online Access:http://www.mdpi.com/2072-6651/2/7/1704/
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spelling doaj-08645c1b4cf842d3b5c45823ea88d3d82020-11-24T21:45:51ZengMDPI AGToxins2072-66512010-06-01271704171710.3390/toxins2071704Uncoupling of T Cell Receptor Zeta Chain Function during the Induction of Anergy by the Superantigen, Staphylococcal Enterotoxin AWilliam D. CornwellThomas J. RogersStaphylococcus aureus enterotoxins have immunomodulatory properties. In this study, we show that Staphylococcal enterotoxin A (SEA) induces a strong proliferative response in a murine T cell clone independent of MHC class II bearing cells. SEA stimulation also induces a state of hypo-responsiveness (anergy). We characterized the components of the T cell receptor (TCR) during induction of anergy by SEA. Most interestingly, TCR zeta chain phosphorylation was absent under SEA anergizing conditions, which suggests an uncoupling of zeta chain function. We characterize here a model system for studying anergy in the absence of confounding costimulatory signals. http://www.mdpi.com/2072-6651/2/7/1704/superantigenStaphylococcus aureusSEAanergyzeta chainenterotoxin
collection DOAJ
language English
format Article
sources DOAJ
author William D. Cornwell
Thomas J. Rogers
spellingShingle William D. Cornwell
Thomas J. Rogers
Uncoupling of T Cell Receptor Zeta Chain Function during the Induction of Anergy by the Superantigen, Staphylococcal Enterotoxin A
Toxins
superantigen
Staphylococcus aureus
SEA
anergy
zeta chain
enterotoxin
author_facet William D. Cornwell
Thomas J. Rogers
author_sort William D. Cornwell
title Uncoupling of T Cell Receptor Zeta Chain Function during the Induction of Anergy by the Superantigen, Staphylococcal Enterotoxin A
title_short Uncoupling of T Cell Receptor Zeta Chain Function during the Induction of Anergy by the Superantigen, Staphylococcal Enterotoxin A
title_full Uncoupling of T Cell Receptor Zeta Chain Function during the Induction of Anergy by the Superantigen, Staphylococcal Enterotoxin A
title_fullStr Uncoupling of T Cell Receptor Zeta Chain Function during the Induction of Anergy by the Superantigen, Staphylococcal Enterotoxin A
title_full_unstemmed Uncoupling of T Cell Receptor Zeta Chain Function during the Induction of Anergy by the Superantigen, Staphylococcal Enterotoxin A
title_sort uncoupling of t cell receptor zeta chain function during the induction of anergy by the superantigen, staphylococcal enterotoxin a
publisher MDPI AG
series Toxins
issn 2072-6651
publishDate 2010-06-01
description Staphylococcus aureus enterotoxins have immunomodulatory properties. In this study, we show that Staphylococcal enterotoxin A (SEA) induces a strong proliferative response in a murine T cell clone independent of MHC class II bearing cells. SEA stimulation also induces a state of hypo-responsiveness (anergy). We characterized the components of the T cell receptor (TCR) during induction of anergy by SEA. Most interestingly, TCR zeta chain phosphorylation was absent under SEA anergizing conditions, which suggests an uncoupling of zeta chain function. We characterize here a model system for studying anergy in the absence of confounding costimulatory signals.
topic superantigen
Staphylococcus aureus
SEA
anergy
zeta chain
enterotoxin
url http://www.mdpi.com/2072-6651/2/7/1704/
work_keys_str_mv AT williamdcornwell uncouplingoftcellreceptorzetachainfunctionduringtheinductionofanergybythesuperantigenstaphylococcalenterotoxina
AT thomasjrogers uncouplingoftcellreceptorzetachainfunctionduringtheinductionofanergybythesuperantigenstaphylococcalenterotoxina
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