A CRE/AP-1-like motif is essential for induced syncytin-2 expression and fusion in human trophoblast-like model.

A CRE/AP-1-like motif is essential for induced syncytin-2 expression and fusion in human trophoblast-like model.

Syncytin-2 is encoded by the envelope gene of Endogenous Retrovirus-FRD (ERVFRD-1) and plays a critical role in fusion of placental trophoblasts leading to the formation of the multinucleated syncytiotrophoblast. Its expression is consequently regulated in a strict manner. In the present study, we h...

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Bibliographic Details
Main Authors: Chirine Toufaily, Adjimon Gatien Lokossou, Amandine Vargas, Éric Rassart, Benoit Barbeau
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4364025?pdf=render

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