SIRT6 Acts as a Negative Regulator in Dengue Virus-Induced Inflammatory Response by Targeting the DNA Binding Domain of NF-κB p65

SIRT6 Acts as a Negative Regulator in Dengue Virus-Induced Inflammatory Response by Targeting the DNA Binding Domain of NF-κB p65

Dengue virus (DENV) is a mosquito-borne single-stranded RNA virus causing human disease with variable severity. The production of massive inflammatory cytokines in dengue patients has been associated with dengue disease severity. However, the regulation of these inflammatory responses remains unclea...

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Bibliographic Details
Main Authors: Pengcheng Li, Yufei Jin, Fei Qi, Fangyi Wu, Susu Luo, Yuanjiu Cheng, Ruth R. Montgomery, Feng Qian
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
SIRT6
dengue virus
proinflammatory cytokines
NF-κB p65
RLR
TLR3
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2018.00113/full

Internet

http://journal.frontiersin.org/article/10.3389/fcimb.2018.00113/full

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