Increased IL-8 concentrations in the cerebrospinal fluid of patients with unipolar depression
Introduction: Unipolar depression is a common and debilitating disorder. Immunological explanatory approaches have become increasingly important in recent years and can be studied particularly well in the cerebrospinal fluid (CSF). Previous studies discerned alterations in interleukin (IL)-6 and IL-...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-10-01
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| Series: | Comprehensive Psychiatry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0010440X20300389 |
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Article |
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DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Hanna Kuzior Bernd L. Fiebich Nizar M. Yousif Soraya W. Saliba Christiane Ziegler Kathrin Nickel Simon J. Maier Patrick Süß Kimon Runge Miriam Matysik Rick Dersch Benjamin Berger Tilman Robinson Nils Venhoff Franziska Kessler Thomas Blank Katharina Domschke Ludger Tebartz van Elst Dominique Endres |
| spellingShingle |
Hanna Kuzior Bernd L. Fiebich Nizar M. Yousif Soraya W. Saliba Christiane Ziegler Kathrin Nickel Simon J. Maier Patrick Süß Kimon Runge Miriam Matysik Rick Dersch Benjamin Berger Tilman Robinson Nils Venhoff Franziska Kessler Thomas Blank Katharina Domschke Ludger Tebartz van Elst Dominique Endres Increased IL-8 concentrations in the cerebrospinal fluid of patients with unipolar depression Comprehensive Psychiatry Interleukin 8 IL-8 Depression Neuroinflammation |
| author_facet |
Hanna Kuzior Bernd L. Fiebich Nizar M. Yousif Soraya W. Saliba Christiane Ziegler Kathrin Nickel Simon J. Maier Patrick Süß Kimon Runge Miriam Matysik Rick Dersch Benjamin Berger Tilman Robinson Nils Venhoff Franziska Kessler Thomas Blank Katharina Domschke Ludger Tebartz van Elst Dominique Endres |
| author_sort |
Hanna Kuzior |
| title |
Increased IL-8 concentrations in the cerebrospinal fluid of patients with unipolar depression |
| title_short |
Increased IL-8 concentrations in the cerebrospinal fluid of patients with unipolar depression |
| title_full |
Increased IL-8 concentrations in the cerebrospinal fluid of patients with unipolar depression |
| title_fullStr |
Increased IL-8 concentrations in the cerebrospinal fluid of patients with unipolar depression |
| title_full_unstemmed |
Increased IL-8 concentrations in the cerebrospinal fluid of patients with unipolar depression |
| title_sort |
increased il-8 concentrations in the cerebrospinal fluid of patients with unipolar depression |
| publisher |
Elsevier |
| series |
Comprehensive Psychiatry |
| issn |
0010-440X |
| publishDate |
2020-10-01 |
| description |
Introduction: Unipolar depression is a common and debilitating disorder. Immunological explanatory approaches have become increasingly important in recent years and can be studied particularly well in the cerebrospinal fluid (CSF). Previous studies discerned alterations in interleukin (IL)-6 and IL-8 levels; however, findings regarding IL-8 were partly contradictory. The aim of the present study was to investigate the concentrations of different cytokines and chemokines, focusing on IL-8, in the CSF of patients with unipolar depression. Materials and methods: Participants included 40 patients with unipolar depression and 39 mentally healthy controls with idiopathic intracranial hypertension. CSF cytokine levels were measured using a magnetic bead multiplexing immunoassay. Results: IL-8 levels in the CSF of the patient group with depression were significantly higher than those in the control group (Mean ± SD: 38.44 ± 6.26 pg/ml versus 21.40 ± 7.96 pg/ml; p < .001). Limitations: The significance of the results is limited by the retrospective design and methodological aspects. Discussion: The main findings of this study were significantly higher concentrations of IL-8 in the CSF of patients with unipolar depression than in the control group. The detection of high CSF IL-8 levels in this study supports the idea that inflammatory processes might play a role in the pathophysiology of a subgroup of patients with depression. |
| topic |
Interleukin 8 IL-8 Depression Neuroinflammation |
| url |
http://www.sciencedirect.com/science/article/pii/S0010440X20300389 |
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doaj-085f0ba2d1d94febbc882152058b71672020-11-25T03:54:06ZengElsevierComprehensive Psychiatry0010-440X2020-10-01102152196Increased IL-8 concentrations in the cerebrospinal fluid of patients with unipolar depressionHanna Kuzior0Bernd L. Fiebich1Nizar M. Yousif2Soraya W. Saliba3Christiane Ziegler4Kathrin Nickel5Simon J. Maier6Patrick Süß7Kimon Runge8Miriam Matysik9Rick Dersch10Benjamin Berger11Tilman Robinson12Nils Venhoff13Franziska Kessler14Thomas Blank15Katharina Domschke16Ludger Tebartz van Elst17Dominique Endres18Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, GermanyDepartment of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, GermanyDepartment of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, GermanyDepartment of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, GermanyDepartment of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, GermanySection for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, GermanySection for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, GermanyDepartment of Molecular Neurology, University Hospital Erlangen, Erlangen, GermanySection for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, GermanySection for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, GermanyDepartment for Neurology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, GermanyDepartment for Neurology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, GermanyDepartment for Neurology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, GermanyDepartment of Rheumatology and Clinical Immunology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, GermanyInstitute of Neuropathology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, GermanyInstitute of Neuropathology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, GermanyDepartment of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Center for Basics in Neuromodulation, Faculty of Medicine, University of Freiburg, GermanySection for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, GermanySection for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Corresponding author at: Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.Introduction: Unipolar depression is a common and debilitating disorder. Immunological explanatory approaches have become increasingly important in recent years and can be studied particularly well in the cerebrospinal fluid (CSF). Previous studies discerned alterations in interleukin (IL)-6 and IL-8 levels; however, findings regarding IL-8 were partly contradictory. The aim of the present study was to investigate the concentrations of different cytokines and chemokines, focusing on IL-8, in the CSF of patients with unipolar depression. Materials and methods: Participants included 40 patients with unipolar depression and 39 mentally healthy controls with idiopathic intracranial hypertension. CSF cytokine levels were measured using a magnetic bead multiplexing immunoassay. Results: IL-8 levels in the CSF of the patient group with depression were significantly higher than those in the control group (Mean ± SD: 38.44 ± 6.26 pg/ml versus 21.40 ± 7.96 pg/ml; p < .001). Limitations: The significance of the results is limited by the retrospective design and methodological aspects. Discussion: The main findings of this study were significantly higher concentrations of IL-8 in the CSF of patients with unipolar depression than in the control group. The detection of high CSF IL-8 levels in this study supports the idea that inflammatory processes might play a role in the pathophysiology of a subgroup of patients with depression.http://www.sciencedirect.com/science/article/pii/S0010440X20300389Interleukin 8IL-8DepressionNeuroinflammation |