Ubiquitination in Periodontal Disease: A Review
Periodontal disease (periodontitis) is a chronic inflammatory condition initiated by microbial infection that leads to gingival tissue destruction and alveolar bone resorption. The periodontal tissue’s response to dental plaque is characterized by the accumulation of polymorphonuclear leukocytes, ma...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2017-07-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/18/7/1476 |
id |
doaj-08554ef536c4489ebad3cc0070b908bf |
---|---|
record_format |
Article |
spelling |
doaj-08554ef536c4489ebad3cc0070b908bf2020-11-24T21:09:59ZengMDPI AGInternational Journal of Molecular Sciences1422-00672017-07-01187147610.3390/ijms18071476ijms18071476Ubiquitination in Periodontal Disease: A ReviewSachio Tsuchida0Mamoru Satoh1Masaki Takiwaki2Fumio Nomura3Division of Clinical Mass Spectrometry, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, JapanDivision of Clinical Mass Spectrometry, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, JapanDivision of Clinical Mass Spectrometry, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, JapanDivision of Clinical Mass Spectrometry, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, JapanPeriodontal disease (periodontitis) is a chronic inflammatory condition initiated by microbial infection that leads to gingival tissue destruction and alveolar bone resorption. The periodontal tissue’s response to dental plaque is characterized by the accumulation of polymorphonuclear leukocytes, macrophages, and lymphocytes, all of which release inflammatory mediators and cytokines to orchestrate the immunopathogenesis of periodontal disease. Ubiquitination is achieved by a mechanism that involves a number of factors, including an ubiquitin-activating enzyme, ubiquitin-conjugating enzyme, and ubiquitin–protein ligase. Ubiquitination is a post-translational modification restricted to eukaryotes that are involved in essential host processes. The ubiquitin system has been implicated in the immune response, development, and programmed cell death. Increasing numbers of recent reports have provided evidence that many approaches are delivering promising reports for discovering the relationship between ubiquitination and periodontal disease. The scope of this review was to investigate recent progress in the discovery of ubiquitinated protein in diseased periodontium and to discuss the ubiquitination process in periodontal diseases.https://www.mdpi.com/1422-0067/18/7/1476ubiquitinationproteasomeperiodontal diseases |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sachio Tsuchida Mamoru Satoh Masaki Takiwaki Fumio Nomura |
spellingShingle |
Sachio Tsuchida Mamoru Satoh Masaki Takiwaki Fumio Nomura Ubiquitination in Periodontal Disease: A Review International Journal of Molecular Sciences ubiquitination proteasome periodontal diseases |
author_facet |
Sachio Tsuchida Mamoru Satoh Masaki Takiwaki Fumio Nomura |
author_sort |
Sachio Tsuchida |
title |
Ubiquitination in Periodontal Disease: A Review |
title_short |
Ubiquitination in Periodontal Disease: A Review |
title_full |
Ubiquitination in Periodontal Disease: A Review |
title_fullStr |
Ubiquitination in Periodontal Disease: A Review |
title_full_unstemmed |
Ubiquitination in Periodontal Disease: A Review |
title_sort |
ubiquitination in periodontal disease: a review |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2017-07-01 |
description |
Periodontal disease (periodontitis) is a chronic inflammatory condition initiated by microbial infection that leads to gingival tissue destruction and alveolar bone resorption. The periodontal tissue’s response to dental plaque is characterized by the accumulation of polymorphonuclear leukocytes, macrophages, and lymphocytes, all of which release inflammatory mediators and cytokines to orchestrate the immunopathogenesis of periodontal disease. Ubiquitination is achieved by a mechanism that involves a number of factors, including an ubiquitin-activating enzyme, ubiquitin-conjugating enzyme, and ubiquitin–protein ligase. Ubiquitination is a post-translational modification restricted to eukaryotes that are involved in essential host processes. The ubiquitin system has been implicated in the immune response, development, and programmed cell death. Increasing numbers of recent reports have provided evidence that many approaches are delivering promising reports for discovering the relationship between ubiquitination and periodontal disease. The scope of this review was to investigate recent progress in the discovery of ubiquitinated protein in diseased periodontium and to discuss the ubiquitination process in periodontal diseases. |
topic |
ubiquitination proteasome periodontal diseases |
url |
https://www.mdpi.com/1422-0067/18/7/1476 |
work_keys_str_mv |
AT sachiotsuchida ubiquitinationinperiodontaldiseaseareview AT mamorusatoh ubiquitinationinperiodontaldiseaseareview AT masakitakiwaki ubiquitinationinperiodontaldiseaseareview AT fumionomura ubiquitinationinperiodontaldiseaseareview |
_version_ |
1716756747293556736 |