Morphological Heterogeneity of p53 Positive and p53 Negative Nuclei in Breast Cancers Stratified by Clinicopathological Variables

Morphological Heterogeneity of p53 Positive and p53 Negative Nuclei in Breast Cancers Stratified by Clinicopathological Variables

The study was aimed to detect differences in nuclear morphology between nuclear populations as well as between tumours with different p53 expression in breast cancers with different clinicopathological features, which also reflect the stage of tumour progression. The p53 immunohistochemistry was per...

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Main Authors: Katrin Friedrich, Volker Dimmer, Gunter Haroske, Wolfdietrich Meyer, Franz Theissig, Berit Thieme, Klaus Dietmar Kunze
Format: Article
Language:English
Published: Hindawi Limited 1997-01-01
Series:Analytical Cellular Pathology
Online Access:http://dx.doi.org/10.1155/1997/619309
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spelling doaj-085502a9705a4b41b74d5933a2e2f2562020-11-25T00:33:00ZengHindawi LimitedAnalytical Cellular Pathology0921-89121878-36511997-01-0114211112310.1155/1997/619309Morphological Heterogeneity of p53 Positive and p53 Negative Nuclei in Breast Cancers Stratified by Clinicopathological VariablesKatrin Friedrich0Volker Dimmer1Gunter Haroske2Wolfdietrich Meyer3Franz Theissig4Berit Thieme5Klaus Dietmar Kunze6Institute of Pathology, Medical Faculty, Technical University, Dresden, GermanyInstitute of Pathology, Medical Faculty, Technical University, Dresden, GermanyInstitute of Pathology, Medical Faculty, Technical University, Dresden, GermanyInstitute of Pathology, Medical Faculty, Technical University, Dresden, GermanyInstitute of Pathology, Medical Faculty, Technical University, Dresden, GermanyInstitute of Pathology, Medical Faculty, Technical University, Dresden, GermanyInstitute of Pathology, Medical Faculty, Technical University, Dresden, GermanyThe study was aimed to detect differences in nuclear morphology between nuclear populations as well as between tumours with different p53 expression in breast cancers with different clinicopathological features, which also reflect the stage of tumour progression. The p53 immunohistochemistry was performed on paraffin sections from 88 tumour samples. After the cells had been localised by means of an image cytometry workstation and their immunostaining had been categorised visually, the sections were destained and stained by the Feulgen protocol. The nuclei were relocated and measured cytometrically by the workstation.http://dx.doi.org/10.1155/1997/619309
collection DOAJ
language English
format Article
sources DOAJ
author Katrin Friedrich
Volker Dimmer
Gunter Haroske
Wolfdietrich Meyer
Franz Theissig
Berit Thieme
Klaus Dietmar Kunze
spellingShingle Katrin Friedrich
Volker Dimmer
Gunter Haroske
Wolfdietrich Meyer
Franz Theissig
Berit Thieme
Klaus Dietmar Kunze
Morphological Heterogeneity of p53 Positive and p53 Negative Nuclei in Breast Cancers Stratified by Clinicopathological Variables
Analytical Cellular Pathology
author_facet Katrin Friedrich
Volker Dimmer
Gunter Haroske
Wolfdietrich Meyer
Franz Theissig
Berit Thieme
Klaus Dietmar Kunze
author_sort Katrin Friedrich
title Morphological Heterogeneity of p53 Positive and p53 Negative Nuclei in Breast Cancers Stratified by Clinicopathological Variables
title_short Morphological Heterogeneity of p53 Positive and p53 Negative Nuclei in Breast Cancers Stratified by Clinicopathological Variables
title_full Morphological Heterogeneity of p53 Positive and p53 Negative Nuclei in Breast Cancers Stratified by Clinicopathological Variables
title_fullStr Morphological Heterogeneity of p53 Positive and p53 Negative Nuclei in Breast Cancers Stratified by Clinicopathological Variables
title_full_unstemmed Morphological Heterogeneity of p53 Positive and p53 Negative Nuclei in Breast Cancers Stratified by Clinicopathological Variables
title_sort morphological heterogeneity of p53 positive and p53 negative nuclei in breast cancers stratified by clinicopathological variables
publisher Hindawi Limited
series Analytical Cellular Pathology
issn 0921-8912
1878-3651
publishDate 1997-01-01
description The study was aimed to detect differences in nuclear morphology between nuclear populations as well as between tumours with different p53 expression in breast cancers with different clinicopathological features, which also reflect the stage of tumour progression. The p53 immunohistochemistry was performed on paraffin sections from 88 tumour samples. After the cells had been localised by means of an image cytometry workstation and their immunostaining had been categorised visually, the sections were destained and stained by the Feulgen protocol. The nuclei were relocated and measured cytometrically by the workstation.
url http://dx.doi.org/10.1155/1997/619309
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AT gunterharoske morphologicalheterogeneityofp53positiveandp53negativenucleiinbreastcancersstratifiedbyclinicopathologicalvariables
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AT beritthieme morphologicalheterogeneityofp53positiveandp53negativenucleiinbreastcancersstratifiedbyclinicopathologicalvariables
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