Polymorphism in the <it>Plasmodium falciparum </it>chloroquine-resistance transporter protein links verapamil enhancement of chloroquine sensitivity with the clinical efficacy of amodiaquine
<p>Abstract</p> <p>Background</p> <p>Chloroquine accumulates in the acidic digestive vacuole of the intraerythrocytic malaria parasite, and prevents the detoxication of haematin released during haemoglobin digestion. Changes in protein PfCRT in the digestive vacuole mem...
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| Format: | Article |
| Language: | English |
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BMC
2003-09-01
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| Series: | Malaria Journal |
| Online Access: | http://www.malariajournal.com/content/2/1/31 |