Design, synthesis, and biological evaluation of novel substituted thiourea derivatives as potential anticancer agents for NSCLC by blocking K-Ras protein-effectors interactions

Design, synthesis, and biological evaluation of novel substituted thiourea derivatives as potential anticancer agents for NSCLC by blocking K-Ras protein-effectors interactions

Mutation of the proto-oncogene K-Ras is one of the most common molecular mechanisms in non-small cell lung cancer. Many drugs for treating lung cancer have been developed, however, due to clinical observed K-Ras mutations, corresponding chemotherapy and targeted therapy for such mutation are not eff...

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Bibliographic Details
Main Authors: Yuan Zhang, Xin Meng, Haikang Tang, Minghui Cheng, Fujun Yang, Wenqing Xu
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
k-ras mutations
malignant carcinoma
anticancer drug
non-small cell lung cancer
a459 cell
Online Access:http://dx.doi.org/10.1080/14756366.2019.1702653

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