Prokineticin Receptor-1 Signaling Inhibits Dose- and Time-Dependent Anthracycline-Induced Cardiovascular Toxicity Via Myocardial and Vascular Protection

Prokineticin Receptor-1 Signaling Inhibits Dose- and Time-Dependent Anthracycline-Induced Cardiovascular Toxicity Via Myocardial and Vascular Protection

Objectives: This study investigated how different concentrations of doxorubicin (DOX) can affect the function of cardiac cells. This study also examined whether activation of prokineticin receptor (PKR)-1 by a nonpeptide agonist, IS20, prevents DOX-induced cardiovascular toxicity in mouse models. Ba...

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Bibliographic Details
Main Authors: Adeline Gasser, PhD, Yu-Wen Chen, MD, PhD, Anais Audebrand, MSci, Ayhan Daglayan, MSci, Marine Charavin, PhD, Brigitte Escoubet, MD, PhD, Pavel Karpov, PhD, Igor Tetko, PhD, Michael W.Y. Chan, PhD, Daniela Cardinale, MD, PhD, Laurent Désaubry, PhD, Canan G. Nebigil, PharmD, PhD
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:JACC. CardioOncology
Subjects:
breast cancer
doxorubicin
endothelial dysfunction
epicardial progenitor cells
heart failure
Online Access:http://www.sciencedirect.com/science/article/pii/S2666087319300043

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