Relationship between triterpenoid anticancer drug resistance, autophagy, and caspase-1 in adult T-cell leukemia

Relationship between triterpenoid anticancer drug resistance, autophagy, and caspase-1 in adult T-cell leukemia

We previously reported that the inflammasome inhibitor cucurbitacin D (CuD) induces apoptosis in human leukemia cell lines. Here, we investigated the effects of CuD and a B-cell lymphoma extra-large (Bcl-xL) inhibitor on autophagy in peripheral blood lymphocytes (PBL) isolated from adult T-cell leuk...

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Bibliographic Details
Main Authors: Tsukasa Nakanishi, Yuan Song, Cuiying He, Duo Wang, Kentaro Morita, Junichi Tsukada, Tamotsu Kanazawa, Yasuhiro Yoshida
Format: Article
Language:English
Published: PeerJ Inc. 2016-05-01
Series:PeerJ
Subjects:
Autophagy
Caspase-1
ATL
Apoptosis
Cucurbitacin D
Online Access:https://peerj.com/articles/2026.pdf

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