Epigenetic alterations are associated with tumor mutation burden in non-small cell lung cancer

Epigenetic alterations are associated with tumor mutation burden in non-small cell lung cancer

Abstract Background To profile genomic and epigenomic of a naïve Chinese non-small cell lung cancer (NSCLC) cohort and investigate the association between tumor mutation burden (TMB) and DNA methylation (DNAm) to explore potential alternative/complimentary biomarkers for NSCLC immunotherapies. Metho...

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Bibliographic Details
Main Authors: Liangliang Cai, Hua Bai, Jianchun Duan, Zhijie Wang, Shugeng Gao, Di Wang, Shuhang Wang, Jun Jiang, Jiefei Han, Yanhua Tian, Xue Zhang, Hao Ye, Minghui Li, Bingding Huang, Jie He, Jie Wang
Format: Article
Language:English
Published: BMJ Publishing Group 2019-07-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
Genetics
Epigenetics
Non-small cell lung cancer
Tumor mutation burden
Checkpoint inhibitor therapy
Online Access:http://link.springer.com/article/10.1186/s40425-019-0660-7

Internet

http://link.springer.com/article/10.1186/s40425-019-0660-7

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