Oxidative Stress Mediates Microcystin-LR-Induced Endoplasmic Reticulum Stress and Autophagy in KK-1 Cells and C57BL/6 Mice Ovaries

Oxidative Stress Mediates Microcystin-LR-Induced Endoplasmic Reticulum Stress and Autophagy in KK-1 Cells and C57BL/6 Mice Ovaries

Microcystin-leucine arginine (MC-LR) is a cyclic heptapeptide intracellular toxin released by cyanobacteria that exhibits strong reproductive toxicity. However, little is known about its biotoxicity to the female reproductive system. The present study investigates unexplored molecular pathways by wh...

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Bibliographic Details
Main Authors: Haohao Liu, Xiaofeng Zhang, Shenshen Zhang, Hui Huang, Jinxia Wu, Yueqin Wang, Le Yuan, Chuanrui Liu, Xin Zeng, Xuemin Cheng, Donggang Zhuang, Huizhen Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Physiology
Subjects:
microcystin-leucine arginine (MC-LR)
oxidative stress
endoplasmic reticulum stress (ERs)
autophagy
N-acetyl-l-cysteine (NAC)
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01058/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.01058/full

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