Emodepside targets SLO-1 channels of Onchocerca ochengi and induces broad anthelmintic effects in a bovine model of onchocerciasis.

Emodepside targets SLO-1 channels of Onchocerca ochengi and induces broad anthelmintic effects in a bovine model of onchocerciasis.

Onchocerciasis (river blindness), caused by the filarial worm Onchocerca volvulus, is a neglected tropical disease mostly affecting sub-Saharan Africa and is responsible for >1.3 million years lived with disability. Current control relies almost entirely on ivermectin, which suppresses symptoms c...

Full description

Bibliographic Details
Main Authors: Germanus S Bah, Sebastian Schneckener, Steffen R Hahnel, Nicolas H Bayang, Helena Fieseler, Gabriele M Schmuck, Ralph Krebber, Anouk Sarr, Carsten Terjung, Henrietta F Ngangyung, David D Ekale, Youssouf M Mfopit, Lucien Rufener, John Graham-Brown, Vincent N Tanya, Martin Glenschek-Sieberth, Daniel Kulke, Benjamin L Makepeace
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-06-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009601

Internet

https://doi.org/10.1371/journal.ppat.1009601

Similar Items