Depression and Quality of Life in Relation to Decreased Glomerular Filtration Rate Among Adults with Hypertension in Rural Northeast China

• Main Authors: Xiaofan Guo, Zhao Li, Shasha Yu, Hongmei Yang, Liang Guo, Liqiang Zheng, Luoning Zhu, Yonghong Zhang, Yingxian Sun
• Format: Article
• Language: English
• Published: Karger Publishers 2015-02-01
• Series: Kidney & Blood Pressure Research
• Subjects: Chronic kidney disease; Depression; Glomerular filtration rate; Hypertension quality of life
• Online Access: http://www.karger.com/Article/FullText/368480
• ISSN: 1420-4096; 1423-0143

Background/Aims: We aim to investigate the extent to which depression and quality of life might be associated with decreased glomerular filtration rate (GFR) in a large hypertensive population in rural Northeast China. Methods: A total of 5566 hypertensive participants aged 35 years and older were screened with a stratified cluster multistage sampling scheme in rural areas of Liaoning Province during 2012-2013. Decreased GFR was defined as estimated GFR 2. Results: The overall prevalence of decreased GFR was 3.2%. In the multivariable regression model, participants with moderate or greater depression had a greater risk for having a decreased GFR (OR: 1.739, 95%CI: 1.004 to 3.014) after full adjustment. Every 1-point increase of all the domains in WHOQOL-BREF, except for physical and environment domains, was significantly related to a lower risk for decreased GFR adjusting for age, gender and race. However, after fully adjustment, only social relations remained significant (OR: 0.899, 95%CI: 0.820 to 0.985). Increasing in total scores of WHOQOL-BREF was a protective factor against decreased GFR after fully adjustment. Conclusion: We found that moderate or greater depression and lower quality of life were associated with higher risks for developing decreased GFR.