Improving Therapeutic Ratio in Head and Neck Cancer with Adjuvant and Cisplatin-Based Treatments

Improving Therapeutic Ratio in Head and Neck Cancer with Adjuvant and Cisplatin-Based Treatments

Advanced head and neck cancers are difficult to manage despite the large treatment arsenal currently available. The multidisciplinary effort to increase disease-free survival and diminish normal tissue toxicity was rewarded with better locoregional control and sometimes fewer side effects. Neverthel...

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Main Author: Loredana G. Marcu
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2013/817279
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spelling doaj-08239a6c7d0c4f258bd467408f13d8332020-11-25T00:20:58ZengHindawi LimitedBioMed Research International2314-61332314-61412013-01-01201310.1155/2013/817279817279Improving Therapeutic Ratio in Head and Neck Cancer with Adjuvant and Cisplatin-Based TreatmentsLoredana G. Marcu0School of Chemistry and Physics, University of Adelaide, Adelaide, SA 5000, AustraliaAdvanced head and neck cancers are difficult to manage despite the large treatment arsenal currently available. The multidisciplinary effort to increase disease-free survival and diminish normal tissue toxicity was rewarded with better locoregional control and sometimes fewer side effects. Nevertheless, locoregional recurrence is still one of the main reasons for treatment failure. Today, the standard of care in head and neck cancer management is represented by altered fractionation radiotherapy combined with platinum-based chemotherapy. Targeted therapies as well as chronotherapy were trialled with more or less success. The aim of the current work is to review the available techniques, which could contribute towards a higher therapeutic ratio in the treatment of advanced head and neck cancer patients.http://dx.doi.org/10.1155/2013/817279
collection DOAJ
language English
format Article
sources DOAJ
author Loredana G. Marcu
spellingShingle Loredana G. Marcu
Improving Therapeutic Ratio in Head and Neck Cancer with Adjuvant and Cisplatin-Based Treatments
BioMed Research International
author_facet Loredana G. Marcu
author_sort Loredana G. Marcu
title Improving Therapeutic Ratio in Head and Neck Cancer with Adjuvant and Cisplatin-Based Treatments
title_short Improving Therapeutic Ratio in Head and Neck Cancer with Adjuvant and Cisplatin-Based Treatments
title_full Improving Therapeutic Ratio in Head and Neck Cancer with Adjuvant and Cisplatin-Based Treatments
title_fullStr Improving Therapeutic Ratio in Head and Neck Cancer with Adjuvant and Cisplatin-Based Treatments
title_full_unstemmed Improving Therapeutic Ratio in Head and Neck Cancer with Adjuvant and Cisplatin-Based Treatments
title_sort improving therapeutic ratio in head and neck cancer with adjuvant and cisplatin-based treatments
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2013-01-01
description Advanced head and neck cancers are difficult to manage despite the large treatment arsenal currently available. The multidisciplinary effort to increase disease-free survival and diminish normal tissue toxicity was rewarded with better locoregional control and sometimes fewer side effects. Nevertheless, locoregional recurrence is still one of the main reasons for treatment failure. Today, the standard of care in head and neck cancer management is represented by altered fractionation radiotherapy combined with platinum-based chemotherapy. Targeted therapies as well as chronotherapy were trialled with more or less success. The aim of the current work is to review the available techniques, which could contribute towards a higher therapeutic ratio in the treatment of advanced head and neck cancer patients.
url http://dx.doi.org/10.1155/2013/817279
work_keys_str_mv AT loredanagmarcu improvingtherapeuticratioinheadandneckcancerwithadjuvantandcisplatinbasedtreatments
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