RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity

RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity

Toll-like receptor 2 (TLR2) is a pattern recognition receptor that recognizes many types of PAMPs that originate from gram-positive bacteria. Here we describe a novel mechanism regulating TLR2 protein expression and subsequent cytokine release through the ubiquitination and degradation of the recept...

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Bibliographic Details
Main Authors: Alison C McKelvey, Travis B Lear, Sarah R Dunn, John Evankovich, James D Londino, Joseph S Bednash, Yingze Zhang, Bryan J McVerry, Yuan Liu, Bill B Chen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-11-01
Series:eLife
Subjects:
TLR2
E3 ligase
ubiquitination
innate immunity
ARDS
Online Access:https://elifesciences.org/articles/18496

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