KGF induces lipogenic genes through a PI3K and JNK/SREBP-1 pathway in H292 cells

KGF induces lipogenic genes through a PI3K and JNK/SREBP-1 pathway in H292 cells

Lipid synthesis is required for cell growth and is subject to pharmacologic regulation. Keratinocyte growth factor (KGF) stimulates proliferation and lipogenesis in H292 cells, a pulmonary epithelial cancer cell line, but the signaling pathways are not known. KGF stimulated the expression of the tra...

Full description

Bibliographic Details
Main Authors:	Yongsheng Chang, Jieru Wang, Xiaojun Lu, Douglas P. Thewke, Robert J. Mason
Format:	Article
Language:	English
Published:	Elsevier 2005-12-01
Series:	Journal of Lipid Research
Subjects:	H292 cells lipogenesis lung cancer keratinocyte growth factor phosphatidylinositol 3-kinase sterol-regulatory element binding protein-1
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520328509

Similar Items

SREBP-1-independent regulation of lipogenic gene expression in adipocytes
by: Motohiro Sekiya, et al.
Published: (2007-07-01)

Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs
by: Takashi Matsuzaka, et al.
Published: (2002-06-01)

Dual regulation of mouse Δ5- and Δ6-desaturase gene expression by SREBP-1 and PPARα
by: Takashi Matsuzaka, et al.
Published: (2002-01-01)

SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression[S]
by: Laurent Vergnes, et al.
Published: (2016-03-01)

20(S)-protopanaxatriol inhibits liver X receptor α-mediated expression of lipogenic genes in hepatocytes
by: Gyun-Sik Oh, et al.
Published: (2015-06-01)

E4BP4 is an insulin-induced stabilizer of nuclear SREBP-1c and promotes SREBP-1c-mediated lipogenesis[S]
by: Xin Tong, et al.
Published: (2016-07-01)

Effects of sterol regulatory element-binding protein (SREBP) in chickens
by: Alipour Fahimeh, et al.
Published: (2012-02-01)

Estrogen stimulates SREBP2 expression in hepatic cell lines via an estrogen response element in the SREBP2 promoter
by: Ye Meng, et al.
Published: (2019-12-01)

Identification of twenty-three mutations in fission yeast Scap that constitutively activate SREBP*
by: Adam L. Hughes, et al.
Published: (2008-09-01)

A novel JNK2/SREBP-1c pathway involved in insulin-induced fatty acid synthesis in human adipocytes
by: Minoru Ito, et al.
Published: (2013-06-01)

Cholesterol accumulation and diabetes in pancreatic β-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity
by: Mayumi Ishikawa, et al.
Published: (2008-12-01)

Low-temperature effect on the sterol-dependent processing of SREBPs and transcription of related genes in HepG2 cells
by: Ishaiahu Shechter, et al.
Published: (2003-08-01)

Glycogen Synthase Kinase 3 Inactivation Induces Cell Senescence through Sterol Regulatory Element Binding Protein 1-Mediated Lipogenesis in Chang Cells
by: You-Mie Kim, et al.
Published: (2013-12-01)

ABCA7 expression is regulated by cellular cholesterol through the SREBP2 pathway and associated with phagocytosis
by: Noriyuki Iwamoto, et al.
Published: (2006-09-01)

Zinc mediates the SREBP-SCD axis to regulate lipid metabolism in Caenorhabditis elegans[S]
by: Jing-Jing Zhang, et al.
Published: (2017-09-01)

Pré-textuais / Sumário 29.2
by: Yara Elizabeth Alves
Published: (2020-09-01)

UV-Induced Reduction of ACVR1C Decreases SREBP1 and ACC Expression by the Suppression of SMAD2 Phosphorylation in Normal Human Epidermal Keratinocytes
by: Yu-Dan Tian, et al.
Published: (2021-01-01)

Cholesterol supply and SREBPs modulate transcription of the Niemann-Pick C-1 gene in steroidogenic tissues
by: Nicolas Gévry, et al.
Published: (2008-05-01)

Disturbances in the normal regulation of SREBP-sensitive genes in PPARα-deficient mice
by: Dilip D. Patel, et al.
Published: (2001-03-01)

Identification of Combined Genetic Determinants of Liver Stiffness within the SREBP1c-PNPLA3 Pathway
by: Frank Lammert, et al.
Published: (2013-10-01)

Docosahexaneoic acid (22:6,n-3) regulates rat hepatocyte SREBP-1 nuclear abundance by Erk- and 26S proteasome-dependent pathways
by: Daniela Botolin, et al.
Published: (2006-01-01)

The steroidal analog GW707 activates the SREBP pathway through disruption of intracellular cholesterol trafficking
by: Jessie Zhang, et al.
Published: (2004-02-01)

Interplay between ChREBP and SREBP-1c coordinates postprandial glycolysis and lipogenesis in livers of mice[S]
by: Albert G. Linden, et al.
Published: (2018-03-01)

IDH1 gene transcription is sterol regulated and activated by SREBP-1a and SREBP-2 in human hepatoma HepG2 cells
by: Ishaiahu Shechter, et al.
Published: (2003-11-01)

Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes
by: Michiyo Amemiya-Kudo, et al.
Published: (2002-08-01)

SREBP-2, a new target of metformin?
by: Zhang F, et al.
Published: (2018-12-01)

Hepatic insulin receptor deficiency impairs the SREBP-2 response to feeding and statins[S]
by: Ji Miao, et al.
Published: (2014-04-01)

SREBP1-Induced Glutamine Synthetase Triggers a Feedforward Loop to Upregulate SREBP1 through Sp1 O-GlcNAcylation and Augments Lipid Droplet Formation in Cancer Cells
by: Jin-Wei Jhu, et al.
Published: (2021-09-01)

Role of the AMPK/SREBP-1 pathway in the development of orotic acid-induced fatty liver
by: Eun-Jeong Jung, et al.
Published: (2011-09-01)

Aβ inhibits SREBP-2 activation through Akt inhibition
by: Amany Mohamed, et al.
Published: (2018-01-01)

Regulation of the human prostacyclin receptor gene by the cholesterol-responsive SREBP1
by: Elizebeth C. Turner, et al.
Published: (2012-11-01)

KGF-1 and KGF receptor expression in human periodontal disease and in vitro microwounding-associated-ligand-independent KGFR activation
by: Li, Min
Published: (2008)

KGF-1 and KGF receptor expression in human periodontal disease and in vitro microwounding-associated-ligand-independent KGFR activation
by: Li, Min
Published: (2008)

KGF-1 and KGF receptor expression in human periodontal disease and in vitro microwounding-associated-ligand-independent KGFR activation
by: Li, Min
Published: (2008)

Sex-related differences of lipid metabolism induced by triptolide: The possible role of the LXRα/SREBP-1 signaling pathway
by: Zhenzhou eJiang, et al.
Published: (2016-03-01)

Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice
by: Kara N. Maxwell, et al.
Published: (2003-11-01)

Fucoidan improves serum lipid levels and atherosclerosis through hepatic SREBP-2-mediated regulation
by: Jinhee Park, et al.
Published: (2016-06-01)

SREBP1 is required for the induction by glucose of pancreatic β-cell genes involved in glucose sensings⃞
by: Frederique Diraison, et al.
Published: (2008-04-01)

Comparison of the expression and activity of the lipogenic pathway in human and rat adipose tissue
by: Dominique Letexier, et al.
Published: (2003-11-01)

B cell receptor pathway in chronic lymphocytic leukemia: specific role of CC-292
by: Arnason JE, et al.
Published: (2014-01-01)

Cannot write session to /tmp/vufind_sessions/sess_38lf4vu06ribht9bnjb4vd4sgj