A Mutation in DNA Polymerase α Rescues <i>WEE1</i><sup>KO</sup> Sensitivity to HU

A Mutation in DNA Polymerase α Rescues <i>WEE1</i><sup>KO</sup> Sensitivity to HU

During DNA replication, the WEE1 kinase is responsible for safeguarding genomic integrity by phosphorylating and thus inhibiting cyclin-dependent kinases (CDKs), which are the driving force of the cell cycle. Consequentially, <i>wee1</i> mutant plants fail to respond properly to problems...

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Bibliographic Details
Main Authors: Thomas Eekhout, José Antonio Pedroza-Garcia, Pooneh Kalhorzadeh, Geert De Jaeger, Lieven De Veylder
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
replication stress
DNA damage
cell cycle checkpoint
Online Access:https://www.mdpi.com/1422-0067/22/17/9409

Internet

https://www.mdpi.com/1422-0067/22/17/9409

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