Assessing VEGF mRNA and miR-494 expression in peripheral blood collected from patients suffering from oral squamous cell carcinoma

• Main Authors: Maryam Masoum Khani, Abdolreza Mohamadnia, Farzaneh Hosseini, Parisa Bayat, Naghmeh Bahrami
• Format: Article
• Language: English
• Published: Tehran University of Medical Sciences 2019-08-01
• Series: Journal of Craniomaxillofacial Research
• Subjects: Oral squamous cell carcinoma; Early diagnosis; VEGF mRNA; miR-494
• Online Access: https://jcr.tums.ac.ir/index.php/jcr/article/view/290

Introduction: Oral squamous cell carcinoma accounts for 2% of all cancers and also is one of  the top 10 causes of death in humans. The goal of this article is to assess changes of VEGF mRNA and miR-494 expression. Materials and Methods: We chose 30 patients with OSCC and 30 healthy people (as a controlled group) and assess the rate of VEGF mRNA and miR-494 expression in peripheral blood with real-time PCR technique. Findings: VEGF mRNA marker was positive in 24 out of 30 patients. Also, miR-494 was positive in 20 out of 30 patients. Results: Overall based on this article’s findings, results could count as a diagnostic screening test for OSCC  detection in early steps of cancer.