Factors associated with hand joint destruction in Chinese patients with rheumatoid arthritis

Abstract Background There have been no previous report of hand joint destruction prevalence in Chinese rheumatoid arthritis (RA) patients. Therefore, the aim of this study was to investigate the prevalence and potential factors of hand joint destruction among RA patients from Nantong China. In addit...

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Main Authors: Lijuan Zhang, Jing Wang, Qiuxiang Zhang, Ting Fu, Rulan Yin, Ze Wang, Liren Li, Xianhua Wu, Zhifeng Gu
Format: Article
Language:English
Published: BMC 2017-05-01
Series:BMC Musculoskeletal Disorders
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12891-017-1548-7
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spelling doaj-07eb451c91164995a1b7211b192e12b42020-11-24T21:39:45ZengBMCBMC Musculoskeletal Disorders1471-24742017-05-011811910.1186/s12891-017-1548-7Factors associated with hand joint destruction in Chinese patients with rheumatoid arthritisLijuan Zhang0Jing Wang1Qiuxiang Zhang2Ting Fu3Rulan Yin4Ze Wang5Liren Li6Xianhua Wu7Zhifeng Gu8Department of Rheumatology, Affiliated Hospital of Nantong UniversityDepartment of Medical Image, Affiliated Hospital of Nantong UniversityDepartment of Rheumatology, Affiliated Hospital of Nantong UniversityDepartment of Rheumatology, Affiliated Hospital of Nantong UniversityDepartment of Rheumatology, Affiliated Hospital of Nantong UniversityDepartment of Medical Image, Affiliated Hospital of Nantong UniversitySchool of Nursing, Nantong UniversityDepartment of Medical Image, Affiliated Hospital of Nantong UniversityDepartment of Rheumatology, Affiliated Hospital of Nantong UniversityAbstract Background There have been no previous report of hand joint destruction prevalence in Chinese rheumatoid arthritis (RA) patients. Therefore, the aim of this study was to investigate the prevalence and potential factors of hand joint destruction among RA patients from Nantong China. In addition, we wanted to examine the differences between functional capacity, psychological status, and quality of life in patients with hand joint destruction compared to those without hand joint destruction. Methods A cross-sectional study was conducted from the Affiliated Hospital of Nantong University between July 2015 and June 2016. RA patients completed questionnaires for demographic or clinical variables, the 10-cm Visual Analog Scale for pain, the 28-joint Disease Activity Score-erythrocyte sedimentation rate for disease activity, the Health Assessment Questionnaire-disability index for physical function, the Hospital Anxiety and Depression Scale for anxiety and depression, and the Short Form 36 health survey for quality of life. Laboratory examinations were taken to obtain some biochemical indicators (e.g., rheumatoid factor, anti-cyclic citrullinated peptide antibody). X-ray assessment of hand was performed and hand joint destruction was defined as Sharp score > 0. Independent sample t-test, Mann–Whitney U-test, Chi-square test, and multivariate analysis using backward stepwise logistic regression model were used to analyze these data. Results One hundred and sixty-one RA patients were included in this study. Radiographic findings revealed that almost 47.2% (n = 76) of patients had hand joint destruction. Multivariate analysis found that education ≤ 9 years (p = 0.041), anti-cyclic citrullinated peptide antibody positive (p = 0.021), high disease activity (p = 0.020), and long disease duration (p < 0.001) were important potential risk factors of hand joint destruction. Participants with hand joint destruction tended to have lower physical function and quality of life, and more severe depressive symptoms compared to individuals without hand joint destruction. Conclusions 47.2% of people with RA from Nantong China experienced hand joint destruction. Education, anti-cyclic citrullinated peptide antibody, disease activity, and disease duration had great impacts on hand joint destruction. The results suggested that rheumatologists should pay attention to RA patients’ hand joint destruction, especially those with low education levels, anti-cyclic citrullinated peptide antibody positive, high disease activity, and long disease duration by patient education or other ways to improve patients’ prognosis.http://link.springer.com/article/10.1186/s12891-017-1548-7Rheumatoid arthritisHand joint destructionDisease activityQuality of life
collection DOAJ
language English
format Article
sources DOAJ
author Lijuan Zhang
Jing Wang
Qiuxiang Zhang
Ting Fu
Rulan Yin
Ze Wang
Liren Li
Xianhua Wu
Zhifeng Gu
spellingShingle Lijuan Zhang
Jing Wang
Qiuxiang Zhang
Ting Fu
Rulan Yin
Ze Wang
Liren Li
Xianhua Wu
Zhifeng Gu
Factors associated with hand joint destruction in Chinese patients with rheumatoid arthritis
BMC Musculoskeletal Disorders
Rheumatoid arthritis
Hand joint destruction
Disease activity
Quality of life
author_facet Lijuan Zhang
Jing Wang
Qiuxiang Zhang
Ting Fu
Rulan Yin
Ze Wang
Liren Li
Xianhua Wu
Zhifeng Gu
author_sort Lijuan Zhang
title Factors associated with hand joint destruction in Chinese patients with rheumatoid arthritis
title_short Factors associated with hand joint destruction in Chinese patients with rheumatoid arthritis
title_full Factors associated with hand joint destruction in Chinese patients with rheumatoid arthritis
title_fullStr Factors associated with hand joint destruction in Chinese patients with rheumatoid arthritis
title_full_unstemmed Factors associated with hand joint destruction in Chinese patients with rheumatoid arthritis
title_sort factors associated with hand joint destruction in chinese patients with rheumatoid arthritis
publisher BMC
series BMC Musculoskeletal Disorders
issn 1471-2474
publishDate 2017-05-01
description Abstract Background There have been no previous report of hand joint destruction prevalence in Chinese rheumatoid arthritis (RA) patients. Therefore, the aim of this study was to investigate the prevalence and potential factors of hand joint destruction among RA patients from Nantong China. In addition, we wanted to examine the differences between functional capacity, psychological status, and quality of life in patients with hand joint destruction compared to those without hand joint destruction. Methods A cross-sectional study was conducted from the Affiliated Hospital of Nantong University between July 2015 and June 2016. RA patients completed questionnaires for demographic or clinical variables, the 10-cm Visual Analog Scale for pain, the 28-joint Disease Activity Score-erythrocyte sedimentation rate for disease activity, the Health Assessment Questionnaire-disability index for physical function, the Hospital Anxiety and Depression Scale for anxiety and depression, and the Short Form 36 health survey for quality of life. Laboratory examinations were taken to obtain some biochemical indicators (e.g., rheumatoid factor, anti-cyclic citrullinated peptide antibody). X-ray assessment of hand was performed and hand joint destruction was defined as Sharp score > 0. Independent sample t-test, Mann–Whitney U-test, Chi-square test, and multivariate analysis using backward stepwise logistic regression model were used to analyze these data. Results One hundred and sixty-one RA patients were included in this study. Radiographic findings revealed that almost 47.2% (n = 76) of patients had hand joint destruction. Multivariate analysis found that education ≤ 9 years (p = 0.041), anti-cyclic citrullinated peptide antibody positive (p = 0.021), high disease activity (p = 0.020), and long disease duration (p < 0.001) were important potential risk factors of hand joint destruction. Participants with hand joint destruction tended to have lower physical function and quality of life, and more severe depressive symptoms compared to individuals without hand joint destruction. Conclusions 47.2% of people with RA from Nantong China experienced hand joint destruction. Education, anti-cyclic citrullinated peptide antibody, disease activity, and disease duration had great impacts on hand joint destruction. The results suggested that rheumatologists should pay attention to RA patients’ hand joint destruction, especially those with low education levels, anti-cyclic citrullinated peptide antibody positive, high disease activity, and long disease duration by patient education or other ways to improve patients’ prognosis.
topic Rheumatoid arthritis
Hand joint destruction
Disease activity
Quality of life
url http://link.springer.com/article/10.1186/s12891-017-1548-7
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