A gD&gC-substituted pseudorabies virus vaccine strain provides complete clinical protection and is helpful to prevent virus shedding against challenge by a Chinese pseudorabies variant

A gD&gC-substituted pseudorabies virus vaccine strain provides complete clinical protection and is helpful to prevent virus shedding against challenge by a Chinese pseudorabies variant

Abstract Background Since 2011, pseudorabies caused by a variant PRV has re-emerged in many Chinese Bartha-K61-vaccinated pig farms. An efficacious vaccine is necessary to control this disease. We described the construction of a gD&gC-substituted pseudorabies virus (PRV B-gD&gCS) from the Ba...

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Bibliographic Details
Main Authors: Chuanjian Zhang, Yamei Liu, Saisai Chen, Yongfeng Qiao, Mingpeng Guo, Yating Zheng, Mengwei Xu, Zhisheng Wang, Jibo Hou, Jichun Wang
Format: Article
Language:English
Published: BMC 2019-01-01
Series:BMC Veterinary Research
Subjects:
Bacterial artificial chromosome
gD&gC substitution
Immunogenicity
Pseudorabies virus
Safety
Online Access:http://link.springer.com/article/10.1186/s12917-018-1766-8

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