Relationship between optical coherence tomography sector peripapillary angioflow-density and Octopus visual field cluster mean defect values.

PURPOSE:To compare the relationship of Octopus perimeter cluster mean-defect (cluster MD) values with the spatially corresponding optical coherence tomography (OCT) sector peripapillary angioflow vessel-density (PAFD) and sector retinal nerve fiber layer thickness (RNFLT) values. METHODS:High qualit...

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Main Author: Gábor Holló
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5289610?pdf=render
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spelling doaj-07e1842792a8456a9938466a3b5567882020-11-25T00:02:08ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01122e017154110.1371/journal.pone.0171541Relationship between optical coherence tomography sector peripapillary angioflow-density and Octopus visual field cluster mean defect values.Gábor HollóPURPOSE:To compare the relationship of Octopus perimeter cluster mean-defect (cluster MD) values with the spatially corresponding optical coherence tomography (OCT) sector peripapillary angioflow vessel-density (PAFD) and sector retinal nerve fiber layer thickness (RNFLT) values. METHODS:High quality PAFD and RNFLT images acquired on the same day with the Angiovue/RTVue-XR Avanti OCT (Optovue Inc., Fremont, USA) on 1 eye of 27 stable early-to-moderate glaucoma, 22 medically controlled ocular hypertensive and 13 healthy participants were analyzed. Octopus G2 normal visual field test was made within 3 months from the imaging. RESULTS:Total peripapillary PAFD and RNFLT showed similar strong positive correlation with global mean sensitivity (r-values: 0.6710 and 0.6088, P<0.0001), and similar (P = 0.9614) strong negative correlation (r-values: -0.4462 and -0.4412, P≤0.004) with global MD. Both inferotemporal and superotemporal sector PAFD were significantly (≤0.039) lower in glaucoma than in the other groups. No significant difference between the corresponding inferotemporal and superotemporal parameters was seen. The coefficient of determination (R2) calculated for the relationship between inferotemporal sector PAFD and superotemporal cluster MD (0.5141, P<0.0001) was significantly greater than that between inferotemporal sector RNFLT and superotemporal cluster MD (0.2546, P = 0.0001). The R2 values calculated for the relationships between superotemporal sector PAFD and RNFLT, and inferotemporal cluster MD were similar (0.3747 and 0.4037, respectively, P<0.0001). CONCLUSION:In the current population the relationship between inferotemporal sector PAFD and superotemporal cluster MD was strong. It was stronger than that between inferotemporal sector RNFLT and superotemporal cluster MD. Further investigations are necessary to clarify if our results are valid for other populations and can be usefully applied for glaucoma research.http://europepmc.org/articles/PMC5289610?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Gábor Holló
spellingShingle Gábor Holló
Relationship between optical coherence tomography sector peripapillary angioflow-density and Octopus visual field cluster mean defect values.
PLoS ONE
author_facet Gábor Holló
author_sort Gábor Holló
title Relationship between optical coherence tomography sector peripapillary angioflow-density and Octopus visual field cluster mean defect values.
title_short Relationship between optical coherence tomography sector peripapillary angioflow-density and Octopus visual field cluster mean defect values.
title_full Relationship between optical coherence tomography sector peripapillary angioflow-density and Octopus visual field cluster mean defect values.
title_fullStr Relationship between optical coherence tomography sector peripapillary angioflow-density and Octopus visual field cluster mean defect values.
title_full_unstemmed Relationship between optical coherence tomography sector peripapillary angioflow-density and Octopus visual field cluster mean defect values.
title_sort relationship between optical coherence tomography sector peripapillary angioflow-density and octopus visual field cluster mean defect values.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2017-01-01
description PURPOSE:To compare the relationship of Octopus perimeter cluster mean-defect (cluster MD) values with the spatially corresponding optical coherence tomography (OCT) sector peripapillary angioflow vessel-density (PAFD) and sector retinal nerve fiber layer thickness (RNFLT) values. METHODS:High quality PAFD and RNFLT images acquired on the same day with the Angiovue/RTVue-XR Avanti OCT (Optovue Inc., Fremont, USA) on 1 eye of 27 stable early-to-moderate glaucoma, 22 medically controlled ocular hypertensive and 13 healthy participants were analyzed. Octopus G2 normal visual field test was made within 3 months from the imaging. RESULTS:Total peripapillary PAFD and RNFLT showed similar strong positive correlation with global mean sensitivity (r-values: 0.6710 and 0.6088, P<0.0001), and similar (P = 0.9614) strong negative correlation (r-values: -0.4462 and -0.4412, P≤0.004) with global MD. Both inferotemporal and superotemporal sector PAFD were significantly (≤0.039) lower in glaucoma than in the other groups. No significant difference between the corresponding inferotemporal and superotemporal parameters was seen. The coefficient of determination (R2) calculated for the relationship between inferotemporal sector PAFD and superotemporal cluster MD (0.5141, P<0.0001) was significantly greater than that between inferotemporal sector RNFLT and superotemporal cluster MD (0.2546, P = 0.0001). The R2 values calculated for the relationships between superotemporal sector PAFD and RNFLT, and inferotemporal cluster MD were similar (0.3747 and 0.4037, respectively, P<0.0001). CONCLUSION:In the current population the relationship between inferotemporal sector PAFD and superotemporal cluster MD was strong. It was stronger than that between inferotemporal sector RNFLT and superotemporal cluster MD. Further investigations are necessary to clarify if our results are valid for other populations and can be usefully applied for glaucoma research.
url http://europepmc.org/articles/PMC5289610?pdf=render
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