Disorders of Insulin Synthesis and Secretion in Type 2 Diabetic Suffers after Disaster on ChNPS

• Main Authors: A.N. Kovalenko, I.G. Chikalova, I.N. Muravyova
• Format: Article
• Language: English
• Published: Publishing House Zaslavsky 2012-04-01
• Series: Mìžnarodnij Endokrinologìčnij Žurnal
• Subjects: ionizing radiation, insulin, proinsulin, diabetes mellitus
• Online Access: http://iej.zaslavsky.com.ua/article/view/177178

There have been demonstrated the results of observation of 60 patients with type 2 diabetes mellitus divided into groups: the I one consisted of participants in the rectification of the consequences of the accident (PRCA) got radiation dose 0.25–0.9 Gy (38 persons), the II group included the inhabitants of radiation contaminated territory (accumulated doses during post-accident years on the average 8.3 cGy (15 persons)), the III group consisted of habitants of Kyiv (16 persons). The groups are comparable on age, disease duration, lipid metabolism disorders. The pancreatic insular apparatus functioning was estimated by determining glucose concentration, C-peptide, blood serum proinsulin under 2-hour mixed nutritive load (300 kсal, 80 % of carbohydrates, 20 % of fat and protein). PRCA were found to have increased blood serum concentration of proinsulin stimulated by postprandial glycemia while C-peptide level did not change. That indicates marked insulin resistance combined with insulin deficiency. The inhabitants of contaminated territory have decelerated reaction on postprandial glycemia associated with increased concentration of C-peptide and proinsulin in 120 minutes after nutritive load. In the persons not undergone radiation C-peptide and proinsulin concentration tended to increase, but PRCA had higher level of stimulated proinsulinemia in comparison with the habitants of contaminated territory and Kyiv.