Why do We Use the Concepts of Adult Anesthesia Pharmacology in Developing Brains? Will It Have an Impact on Outcomes? Challenges in Neuromonitoring and Pharmacology in Pediatric Anesthesia

Background: Pediatric sedation and anesthesia techniques have plenty of difficulties and challenges. Data on the pharmacologic, electroencephalographic, and neurologic response to anesthesia at different brain development times are only partially known. New data in neuroscience, pharmacology, and in...

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Main Authors:	Pablo O. Sepúlveda, Valeria Epulef, Gustavo Campos
Format:	Article
Language:	English
Published:	MDPI AG 2021-05-01
Series:	Journal of Clinical Medicine
Subjects:	pediatric anesthesia EEG TIVA propofol neuromaturation synaptogenesis
Online Access:	https://www.mdpi.com/2077-0383/10/10/2175

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spelling	doaj-07ddc04a5b574027a7a9e626432381cb2021-06-01T00:20:36ZengMDPI AGJournal of Clinical Medicine2077-03832021-05-01102175217510.3390/jcm10102175Why do We Use the Concepts of Adult Anesthesia Pharmacology in Developing Brains? Will It Have an Impact on Outcomes? Challenges in Neuromonitoring and Pharmacology in Pediatric AnesthesiaPablo O. Sepúlveda0Valeria Epulef1Gustavo Campos2Hospital Base San José de Osorno, Service Anesthesiology and Pain, Faculty of Medicine, University Austral, Los Lagos 529000, ChileDepartment of Surgery, Traumatology and Anesthesiology, Medicine Faculty, Universidad de La Frontera, Temuco 4780000, ChileHospital Pediatrico Niño Jesús, Service of Anesthesiology, Córdoba 5500, ArgentinaBackground: Pediatric sedation and anesthesia techniques have plenty of difficulties and challenges. Data on the pharmacologic, electroencephalographic, and neurologic response to anesthesia at different brain development times are only partially known. New data in neuroscience, pharmacology, and intraoperative neuromonitoring will impact changing concepts and clinical practice. In this article, we develop a conversation to guide the debate and search for a view more attuned to the updated knowledge in neurodevelopment, electroencephalography, and clinical pharmacology for the anesthesiologic practice in the pediatric population.https://www.mdpi.com/2077-0383/10/10/2175pediatric anesthesiaEEGTIVApropofolneuromaturationsynaptogenesis
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Pablo O. Sepúlveda Valeria Epulef Gustavo Campos
spellingShingle	Pablo O. Sepúlveda Valeria Epulef Gustavo Campos Why do We Use the Concepts of Adult Anesthesia Pharmacology in Developing Brains? Will It Have an Impact on Outcomes? Challenges in Neuromonitoring and Pharmacology in Pediatric Anesthesia Journal of Clinical Medicine pediatric anesthesia EEG TIVA propofol neuromaturation synaptogenesis
author_facet	Pablo O. Sepúlveda Valeria Epulef Gustavo Campos
author_sort	Pablo O. Sepúlveda
title	Why do We Use the Concepts of Adult Anesthesia Pharmacology in Developing Brains? Will It Have an Impact on Outcomes? Challenges in Neuromonitoring and Pharmacology in Pediatric Anesthesia
title_short	Why do We Use the Concepts of Adult Anesthesia Pharmacology in Developing Brains? Will It Have an Impact on Outcomes? Challenges in Neuromonitoring and Pharmacology in Pediatric Anesthesia
title_full	Why do We Use the Concepts of Adult Anesthesia Pharmacology in Developing Brains? Will It Have an Impact on Outcomes? Challenges in Neuromonitoring and Pharmacology in Pediatric Anesthesia
title_fullStr	Why do We Use the Concepts of Adult Anesthesia Pharmacology in Developing Brains? Will It Have an Impact on Outcomes? Challenges in Neuromonitoring and Pharmacology in Pediatric Anesthesia
title_full_unstemmed	Why do We Use the Concepts of Adult Anesthesia Pharmacology in Developing Brains? Will It Have an Impact on Outcomes? Challenges in Neuromonitoring and Pharmacology in Pediatric Anesthesia
title_sort	why do we use the concepts of adult anesthesia pharmacology in developing brains? will it have an impact on outcomes? challenges in neuromonitoring and pharmacology in pediatric anesthesia
publisher	MDPI AG
series	Journal of Clinical Medicine
issn	2077-0383
publishDate	2021-05-01
description	Background: Pediatric sedation and anesthesia techniques have plenty of difficulties and challenges. Data on the pharmacologic, electroencephalographic, and neurologic response to anesthesia at different brain development times are only partially known. New data in neuroscience, pharmacology, and intraoperative neuromonitoring will impact changing concepts and clinical practice. In this article, we develop a conversation to guide the debate and search for a view more attuned to the updated knowledge in neurodevelopment, electroencephalography, and clinical pharmacology for the anesthesiologic practice in the pediatric population.
topic	pediatric anesthesia EEG TIVA propofol neuromaturation synaptogenesis
url	https://www.mdpi.com/2077-0383/10/10/2175
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Why do We Use the Concepts of Adult Anesthesia Pharmacology in Developing Brains? Will It Have an Impact on Outcomes? Challenges in Neuromonitoring and Pharmacology in Pediatric Anesthesia

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