Poliovirus intrahost evolution is required to overcome tissue-specific innate immune responses

Poliovirus intrahost evolution is required to overcome tissue-specific innate immune responses

RNA viruses, such as polioviruses, have a great evolutionary capacity and can adapt quickly during infection. Here, the authors show that poliovirus infection in mice requires adaptation to innate immune microenvironments encountered in different tissues.

Bibliographic Details
Main Authors: Yinghong Xiao, Patrick Timothy Dolan, Elizabeth Faul Goldstein, Min Li, Mikhail Farkov, Leonid Brodsky, Raul Andino
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00354-5
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spelling doaj-07dbb9d5bd994988b91e09463962e4062021-05-11T07:25:01ZengNature Publishing GroupNature Communications2041-17232017-08-018111210.1038/s41467-017-00354-5Poliovirus intrahost evolution is required to overcome tissue-specific innate immune responsesYinghong Xiao0Patrick Timothy Dolan1Elizabeth Faul Goldstein2Min Li3Mikhail Farkov4Leonid Brodsky5Raul Andino6Department of Microbiology and Immunology, University of CaliforniaDepartment of Microbiology and Immunology, University of CaliforniaDepartment of Microbiology and Immunology, University of CaliforniaDepartment of Microbiology and Immunology, University of CaliforniaTauber Bioinformatics Research Center and Department of Evolutionary & Environmental Biology, University of HaifaTauber Bioinformatics Research Center and Department of Evolutionary & Environmental Biology, University of HaifaDepartment of Microbiology and Immunology, University of CaliforniaRNA viruses, such as polioviruses, have a great evolutionary capacity and can adapt quickly during infection. Here, the authors show that poliovirus infection in mice requires adaptation to innate immune microenvironments encountered in different tissues.https://doi.org/10.1038/s41467-017-00354-5
collection DOAJ
language English
format Article
sources DOAJ
author Yinghong Xiao
Patrick Timothy Dolan
Elizabeth Faul Goldstein
Min Li
Mikhail Farkov
Leonid Brodsky
Raul Andino
spellingShingle Yinghong Xiao
Patrick Timothy Dolan
Elizabeth Faul Goldstein
Min Li
Mikhail Farkov
Leonid Brodsky
Raul Andino
Poliovirus intrahost evolution is required to overcome tissue-specific innate immune responses
Nature Communications
author_facet Yinghong Xiao
Patrick Timothy Dolan
Elizabeth Faul Goldstein
Min Li
Mikhail Farkov
Leonid Brodsky
Raul Andino
author_sort Yinghong Xiao
title Poliovirus intrahost evolution is required to overcome tissue-specific innate immune responses
title_short Poliovirus intrahost evolution is required to overcome tissue-specific innate immune responses
title_full Poliovirus intrahost evolution is required to overcome tissue-specific innate immune responses
title_fullStr Poliovirus intrahost evolution is required to overcome tissue-specific innate immune responses
title_full_unstemmed Poliovirus intrahost evolution is required to overcome tissue-specific innate immune responses
title_sort poliovirus intrahost evolution is required to overcome tissue-specific innate immune responses
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-08-01
description RNA viruses, such as polioviruses, have a great evolutionary capacity and can adapt quickly during infection. Here, the authors show that poliovirus infection in mice requires adaptation to innate immune microenvironments encountered in different tissues.
url https://doi.org/10.1038/s41467-017-00354-5
work_keys_str_mv AT yinghongxiao poliovirusintrahostevolutionisrequiredtoovercometissuespecificinnateimmuneresponses
AT patricktimothydolan poliovirusintrahostevolutionisrequiredtoovercometissuespecificinnateimmuneresponses
AT elizabethfaulgoldstein poliovirusintrahostevolutionisrequiredtoovercometissuespecificinnateimmuneresponses
AT minli poliovirusintrahostevolutionisrequiredtoovercometissuespecificinnateimmuneresponses
AT mikhailfarkov poliovirusintrahostevolutionisrequiredtoovercometissuespecificinnateimmuneresponses
AT leonidbrodsky poliovirusintrahostevolutionisrequiredtoovercometissuespecificinnateimmuneresponses
AT raulandino poliovirusintrahostevolutionisrequiredtoovercometissuespecificinnateimmuneresponses
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