Combined Anti-Cancer Effects of Platycodin D and Sorafenib on Androgen-Independent and PTEN-Deficient Prostate Cancer

Combined Anti-Cancer Effects of Platycodin D and Sorafenib on Androgen-Independent and PTEN-Deficient Prostate Cancer

Castration-resistant (androgen-independent) and PTEN-deficient prostate cancer is a challenge in clinical practice. Sorafenib has been recommended for the treatment of this type of cancer, but is associated with several adverse effects. Platycodin D (PD) is a triterpene saponin with demonstrated ant...

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Bibliographic Details
Main Authors: Zongliang Lu, Wei Song, Yaowen Zhang, Changpeng Wu, Mingxing Zhu, He Wang, Na Li, Yong Zhou, Hongxia Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Oncology
Subjects:
Platycodin D
Sorafenib
PTEN
FOXO3a
Akt
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.648985/full

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