Historical and Clinical Experiences of Gene Therapy  for Solid Cancers in China

Historical and Clinical Experiences of Gene Therapy  for Solid Cancers in China

Based on the theoretical and clinical development of modern medicines, gene therapy has been a promising treatment strategy for cancer and other diseases. The practice of gene therapy is nearly 27 years old, since the first authorized gene transfer study took place at the National Institute of Healt...

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Main Authors: Bo Li, Ning Gao, Zhuang Zhang, Qian‐Ming Chen, Long‐Jiang Li, Yi Li
Format: Article
Language:English
Published: MDPI AG 2017-02-01
Series:Genes
Subjects:
gene therapy
 history
 clinical trial
Online Access:http://www.mdpi.com/2073-4425/8/3/85
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spelling doaj-07bfb9e3545142f5a799859e216026102020-11-24T23:53:18ZengMDPI AGGenes2073-44252017-02-01838510.3390/genes8030085genes8030085Historical and Clinical Experiences of Gene Therapy  for Solid Cancers in ChinaBo Li0Ning Gao1Zhuang Zhang2Qian‐Ming Chen3Long‐Jiang Li4Yi Li5State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaBased on the theoretical and clinical development of modern medicines, gene therapy has been a promising treatment strategy for cancer and other diseases. The practice of gene therapy is nearly 27 years old, since the first authorized gene transfer study took place at the National Institute of Health in 1989. However, gene therapy was not readily adopted worldwide, until recently. Several gene therapy clinical trials have been carried out in China since 1998, and medical research in China has flourished. In this report, we review the history of gene therapy in China, focusing on treatment protocol, the administration cycle, dosage calculation, and the evaluation of therapeutic effects, in order to provide more information for the additional development of this promising treatment strategy.http://www.mdpi.com/2073-4425/8/3/85gene therapy history clinical trial
collection DOAJ
language English
format Article
sources DOAJ
author Bo Li
Ning Gao
Zhuang Zhang
Qian‐Ming Chen
Long‐Jiang Li
Yi Li
spellingShingle Bo Li
Ning Gao
Zhuang Zhang
Qian‐Ming Chen
Long‐Jiang Li
Yi Li
Historical and Clinical Experiences of Gene Therapy  for Solid Cancers in China
Genes
gene therapy
 history
 clinical trial
author_facet Bo Li
Ning Gao
Zhuang Zhang
Qian‐Ming Chen
Long‐Jiang Li
Yi Li
author_sort Bo Li
title Historical and Clinical Experiences of Gene Therapy  for Solid Cancers in China
title_short Historical and Clinical Experiences of Gene Therapy  for Solid Cancers in China
title_full Historical and Clinical Experiences of Gene Therapy  for Solid Cancers in China
title_fullStr Historical and Clinical Experiences of Gene Therapy  for Solid Cancers in China
title_full_unstemmed Historical and Clinical Experiences of Gene Therapy  for Solid Cancers in China
title_sort historical and clinical experiences of gene therapy  for solid cancers in china
publisher MDPI AG
series Genes
issn 2073-4425
publishDate 2017-02-01
description Based on the theoretical and clinical development of modern medicines, gene therapy has been a promising treatment strategy for cancer and other diseases. The practice of gene therapy is nearly 27 years old, since the first authorized gene transfer study took place at the National Institute of Health in 1989. However, gene therapy was not readily adopted worldwide, until recently. Several gene therapy clinical trials have been carried out in China since 1998, and medical research in China has flourished. In this report, we review the history of gene therapy in China, focusing on treatment protocol, the administration cycle, dosage calculation, and the evaluation of therapeutic effects, in order to provide more information for the additional development of this promising treatment strategy.
topic gene therapy
 history
 clinical trial
url http://www.mdpi.com/2073-4425/8/3/85
work_keys_str_mv AT boli historicalandclinicalexperiencesofgenetherapyforsolidcancersinchina
AT ninggao historicalandclinicalexperiencesofgenetherapyforsolidcancersinchina
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AT qianmingchen historicalandclinicalexperiencesofgenetherapyforsolidcancersinchina
AT longjiangli historicalandclinicalexperiencesofgenetherapyforsolidcancersinchina
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