Intravenous Administration Is an Effective and Safe Route for Cancer Gene Therapy Using the Bifidobacterium-Mediated Recombinant HSV-1 Thymidine Kinase and Ganciclovir

Intravenous Administration Is an Effective and Safe Route for Cancer Gene Therapy Using the Bifidobacterium-Mediated Recombinant HSV-1 Thymidine Kinase and Ganciclovir

The herpes simplex virus thymidine kinase/ganciclovir (HSV TK/GCV) system is one of the best studied cancer suicide gene therapy systems. Our previous study showed that caspase 3 expression was upregulated and bladder tumor growth was significantly reduced in rats treated with a combination of Bifid...

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Bibliographic Details
Main Authors: Huicong Zhou, Zhiliang He, Changdong Wang, Tingting Xie, Lin Liu, Chuanyang Liu, Fangzhou Song, Yongping Ma
Format: Article
Language:English
Published: MDPI AG 2016-06-01
Series:International Journal of Molecular Sciences
Subjects:
cancer
gene therapy
Bifidobacterium
safety
thymidine kinase
ganciclovir
vascular endothelial growth factor (VEGF)
Online Access:http://www.mdpi.com/1422-0067/17/6/891

Internet

http://www.mdpi.com/1422-0067/17/6/891

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