Absence of miRNA-146a Differentially Alters Microglia Function and Proteome

Absence of miRNA-146a Differentially Alters Microglia Function and Proteome

Background: MiR-146a is an important regulator of innate inflammatory responses and is also implicated in cell death and survival.Methods: By sorting CNS resident cells, microglia were the main cellular source of miR-146a. Therefore, we investigated microglia function and phenotype in miR-146a knock...

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Bibliographic Details
Main Authors: Nellie A. Martin, Kirsten H. Hyrlov, Maria L. Elkjaer, Eva K. Thygesen, Agnieszka Wlodarczyk, Kirstine J. Elbaek, Christopher Aboo, Justyna Okarmus, Eirikur Benedikz, Richard Reynolds, Zoltan Hegedus, Allan Stensballe, Åsa Fex Svenningsen, Trevor Owens, Zsolt Illes
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
miR-146a
microglia
cuprizone
multiple sclerosis lesion
proteome
phagocytosis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01110/full

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