The Effects of Hydro-alcoholic Extract of Raspberry Fruit on Ovarian follicles and serum parameters in Poly Cystic Ovary Syndrome-Induced Rat

• Main Authors: mohamad Nabiuni, seyedeh rezvan *, Panahandeh, solmaz , Doostikhah, latefeh Karimzadeh Bardei
• Format: Article
• Language: fas
• Published: Yasuj University Of Medical Sciences 2015-02-01
• Series: Armaghane Danesh Bimonthly Journal
• Subjects: Poly Cystic Ovary Syndrome; Raspberry; Estradiol valerate; Corpus luteums
• Online Access: http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-1-15&slc_lang=en&sid=1

Background & aim: Polycystic Ovary Syndrome is an endocrine disorder leading to lack of ovulation and has inflammatory aspects. Raspberry extract, with possession of bioactive compounds such as Anthocyanins and polyphenols, have anti-inflammatory properties. In this study, the anti-inflammatory effects of raspberry extract on the development process of ovarian follicles and hormones level of pituitary, ovarian, and liver in rats suffering from PCOS were examined. Methods: In the present experimental study, 120 adult Wistar rats were divided into three groups of control, PCOS, and treated with raspberry. The induction of syndrome was done by 2mg Estradiol valerate. After a period of 60 days, 100, 150 and 200 mg/kg BW raspberry extract was injected intraperitoneally. Control group received no injection. Ten days after the last injection, all groups were anesthetized by chloroform and the serum and ovary of all groups were collected in order to investigate the histological and serologic changes. Data obtained were analyzed by using one-way ANOVA. Results: Raspberry-treated group showed a significant decrease in the hormones rate of testosterone, estradiol, LH, and CRP compared with PCOS (p<0.05), whereas a significant increase was observed in the serum level of Progesterone and FSH (p<0.05). A significant increase was observed in the number of corpus luteum and granulosa layer thickness in the raspberry-treated group compared with PCOS (p<0.05). Conclusion: The results demonstrated that the antioxidant and anti-inflammatory effects of raspberry extract was effective on regulating the hormones, CRPand improving of cysts which led to the initiation of ovulation.