Linderane Suppresses Hepatic Gluconeogenesis by Inhibiting the cAMP/PKA/CREB Pathway Through Indirect Activation of PDE 3 via ERK/STAT3

Linderane Suppresses Hepatic Gluconeogenesis by Inhibiting the cAMP/PKA/CREB Pathway Through Indirect Activation of PDE 3 via ERK/STAT3

The role of phosphodiesterase 3 (PDE3), a cyclic AMP (cAMP)-degrading enzyme, in modulating gluconeogenesis remains unknown. Here, linderane, a natural compound, was found to inhibit gluconeogenesis by activating hepatic PDE3 in rat primary hepatocytes. The underlying molecular mechanism and its eff...

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Bibliographic Details
Main Authors: Wei Xie, Yangliang Ye, Ying Feng, Tifei Xu, Suling Huang, Jianhua Shen, Ying Leng
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Pharmacology
Subjects:
cAMP
gluconeogenesis
linderane
phosphodiesterase
type 2 diabetes
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00476/full

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